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negative effects of the disease. Thus, a targeted therapy that could mitigate the inflammatory processes within the joint to prevent damage in the early stages of disease would be very beneficial. Recent studies have suggested that extracellular vesicles

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in Journal of the American Veterinary Medical Association

markers of EVs in a sample. The International Society of Extracellular Vesicles 7 , 8 stated that minimal EV identification and characterization criteria include transmission electron microscopy or scanning electron microscopy size assessment

Open access
in Journal of the American Veterinary Medical Association

variety of medical conditions with varying severity of disease. Taken together, these variables have made it extremely difficult to define the clinical efficacy of SC treatments and develop best practices for their use. 7 Extracellular Vesicles and

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in Journal of the American Veterinary Medical Association

table. Table 2 Differentially expressed plasma and synovial fluid extracellular vesicle microRNAs (miRNAs) with the highest and lowest log2 fold change (LogFC) when comparing horses with PTOA to control horses. Plasma miRNAs LogFC

Open access
in Journal of the American Veterinary Medical Association

Extracellular vesicles are composed of a lipid bilayer that is produced by various cell types. These vesicles are primarily categorized by mode of biogenesis into 3 classes: exosomes, microvesicles, and apoptotic bodies. Exosomes are formed as the

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in American Journal of Veterinary Research

. Extracellular vesicles were isolated from plasma samples by means of ultracentrifugation, as described previously. 30 Briefly, 0.3 mL of plasma was mixed %%%with 1.2 mL of PBS solution. The mixture was placed in a centrifuge with a swinging bucket rotor b and

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in American Journal of Veterinary Research
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disease control. Her interest in noncoding RNA and extracellular vesicle signaling extends into her studies of cardiovascular toxicity secondary to anticancer treatment in veterinary patients. These noncoding RNAs, especially in the context of their

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in American Journal of Veterinary Research
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supporting the need for further investigation. Keeping with a similar theme, Soltero-Rivera et al 4 examine extracellular vesicles (EVs) derived from feline adipose mesenchymal stromal cells (ASCs) and placenta mesenchymal stromal cells (PMSCs) . In this

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in Journal of the American Veterinary Medical Association

. It is now known that MSCs produce extracellular vesicles as part of this paracrine signal to transfer nucleic acids, proteins, lipids, and growth factors to affect the behavior of existing adult cells such as cardiomyocytes or existing progenitor

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in American Journal of Veterinary Research

lies in the export of miRNAs from cells, either in extracellular vesicles or associated with Ago proteins. 45 , 46 , 47 Extracellular vesicles and miRNA-Ago protein complexes are exported from cells into circulation from both active cells and those

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in American Journal of Veterinary Research