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azotemia were not proteinuric, a condition that has also been described in humans with type 1 and type 2 diabetes mellitus. 33,35 The underlying mechanisms for this result are unclear, and because renal ultrastructural information was not obtained, only

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in American Journal of Veterinary Research

renal tubular damage in both insulin-dependent and non–insulin dependent diabetes mellitus 31,32 and in human patients with systemic hypertension. 33 In dogs, NAG activity has been used as a marker of tubular damage in patients with CKD resulting from

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in American Journal of Veterinary Research

(eg, hyperadrenocorticism, diabetes mellitus, or neoplasia). Gastrointestinal protectants (eg, H 2 -receptor blockers and proton-pump blockers) were not routinely administered as part of this study; however, administration of protectants was not a

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in American Journal of Veterinary Research

-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus . Cardiovasc Diabetol 2010 ; 9 : 70 . 10.1186/1475-2840-9-70 46. Wang IC , Hsu WL , Wu PH

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in American Journal of Veterinary Research

OM , et al. Urinary excretion of n-acetyl-b-D-glucosaminidase and retinol binding protein as alternative indicators of nephropathy in patients with type 1 diabetes mellitus . Pediatr Diabetes 2002 ; 3 : 37 – 41 . 10.1034/j.1399-5448.2002.30107.x

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in American Journal of Veterinary Research