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metabolic alterations that are associated with obesity in humans, including insulin resistance, dyslipidemia, and atherosclerosis. 16 Leptin is an important regulator of energy homeostasis, neuroendocrine function, and metabolism. It increases insulin

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in American Journal of Veterinary Research

Care 2015 ; 30 : 90 – 96 . 10.1016/j.jcrc.2014.10.006 25. Padberg JS , Wiesinger A , di Marco GS , Damage of the endothelial glycocalyx in chronic kidney disease . Atherosclerosis 2014 ; 234 : 335 – 343 . 10.1016/j.atherosclerosis

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in American Journal of Veterinary Research

traditional and novel vascular risk factors in young, non-obese healthy subjects . Atherosclerosis 2007 ; 193 : 213 – 221 . 10.1016/j.atherosclerosis.2006.06.018 12. LeBlanc CJ Dietrich MA Horohov DW , et al. Effects of dietary fish oil and

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in American Journal of Veterinary Research

, Higgins JA , Taylor T , et al. A novel method for the rapid separation of human plasma lipoproteins using self-generating gradients of iodixanol . Atherosclerosis 1996 ; 124 : 125 – 135 . 10

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in American Journal of Veterinary Research

atherosclerosis due to hypervitaminosis D . Am J Pathol 1960 ; 37 : 521 – 549 . 39. Capen CC Cole CR Hibbs JW . The pathology of hypervitaminosis D in cattle . Pathol Vet 1966 ; 3 : 350 – 378 . 40. Hilbe M Sydler T Fischer L , et al

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in American Journal of Veterinary Research

combination with aspirin for its antiaggregatory action in humans with atherosclerosis and acute coronary syndromes. The efficacy of clopidogrel in such patients is related to prodrug metabolism by the hepatic cytochrome P450 system. Interindividual variation

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in American Journal of Veterinary Research