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SUMMARY

Objective

To determine how long serum concentrations of ω-3 fatty acids remain elevated after cessation of dietary fish oil supplementation.

Animals

12 healthy Beagles.

Procedure

Baseline serum concentrations of linoleic acid, linolenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were measured. Dogs were then fed a diet supplemented with soybean oil or fish oil for 8 weeks, and serum fatty acid concentrations were measured while dogs were fed the experimental diets and for 18 weeks after they were switched to a maintenance diet.

Results

For dogs fed the fish oil diet, serum EPA and DHA concentrations were significantly increased by week 1 and remained increased for 7 (DHA concentration) or 3 (EPA concentration) weeks after dietary fish oil supplementation was discontinued.

Conclusions

In dogs, supplementation of the diet with fish oil may have effects for several weeks after dietary supplementation is discontinued.

Clinical Relevance

Studies of the effects of fish oil supplementation that use a crossover design should allow for an appropriate washout period. (Am J Vet Res 1998;59:864–868)

Free access
in American Journal of Veterinary Research

Abstract

Objective

To determine effects of dietary cysteine on blood sulfur amino acids (SAA), reduced glutathione (GSH), oxidized glutathione (GSSG), and malondialdehyde (MDA) concentrations in cats.

Animals

12 healthy adult cats.

Procedure

Cats were fed diets with a nominal (0.50 g/100 g dry matter [DM]), moderate (1.00 g/100 g DM), or high (1.50 g/100 g DM) cysteine content in a 3 × 3 Latin square design with blocks of 8 weeks’ duration. Venous blood samples were collected after each diet had been fed for 4 and 8 weeks, and a CBC and serum biochemical analyses were performed; poikilocyte, reticulocyte, and Heinz body counts were determined; and MDA, GSH, GSSG, and SAA concentrations were measured.

Results

Blood cysteine and MDA concentrations were not significantly affected by dietary cysteine content. Blood methionine, homocysteine, and GSSG concentrations were significantly increased when cats consumed the high cysteine content diet but not when they consumed the moderate cysteine content diet, compared with concentrations obtained when cats consumed the nominal cysteine content diet. Blood GSH concentrations were significantly increased when cats consumed the moderate or high cysteine content diet.

Conclusions

Increased dietary cysteine content promotes higher blood methionine, homocysteine, GSH, and GSSG concentrations in healthy cats.

Clinical Relevance

Supplemental dietary cysteine may be indicated to promote glutathione synthesis and ameliorate adverse effects of oxidative damage induced by disease or drugs. (Am J Vet Res 1999;60:328–333)

Free access
in American Journal of Veterinary Research