Objective—To determine whether amlodipine besylate
decreases systemic arterial blood pressure (BP)
and reduces the prevalence of complications in cats
with induced hypertensive renal insufficiency.
Animals—20 cats with partial nephrectomy.
Procedure—Following reduction in renal mass, 10
cats were administered 0.25 mg of amlodipine/kg,
PO, q 24 h (group A). Ten cats served as a control
group (group C). Systolic BP (SBP), diastolic BP (DBP),
and mean BP (MBP), physical activity, and pulse rate
were measured continuously for 36 days by use of
Results—Compared with values for clinically normal
cats, SBP, DBP, and MBP were significantly increased
in cats of group C. Cats in group A had significant
reductions in SBP, DBP, and MBP, compared with values
for cats in group C. Albuminuria but not urine protein-
to-creatinine ratio was significantly correlated
( R2 = 0.317) with SBP in hypertensive cats.
Prevalence of ocular lesions attributable to systemic
hypertension in group C (7 cats) was greater than that
observed in group A (2). Two cats in group C were
euthanatized on day 16 because of nuerologic complications
attributed to systemic hypertension. One normotensive
cat in group A was euthanatized because
of purulent enteritis of unknown cause on day 27.
Conclusion and Clinical Relevance—Amlodipine
had an antihypertensive effect in cats with coexistent
systemic hypertension and renal insufficiency. Its use
may improve the prognosis for cats with systemic
hypertension by decreasing the risk of ocular injury or
neurologic complications induced by high BP. (Am J
Vet Res 2002;63:833–839)