Search Results
You are looking at 1 - 3 of 3 items for
- Author or Editor: James E. Bailey x
- Refine by Access: Content accessible to me x
Objective—
To determine the median effective dose (ED50) of propofol required for induction of anesthesia in goats and the frequency of myoclonic activity and apnea associated with propofol administration.
Design—
Clinical trial.
Animals—
28 healthy mature goats.
Procedure—
ED50 was determined by use of the up-and-down method. The first goat was given 4 mg of propofol/kg (1.8 mg/lb) of body weight, IV. Dose was increased by 25% for the next goat if endotracheal intubation was not possible and decreased by 20% if it was. For each subsequent goat, dose was determined on the basis of response of the previous goat. The ED50 was calculated by use of probit analysis. Induction time, frequency and duration of apnea, frequency of myoclonus, and other adverse effects were recorded.
Results—
ED50 was determined to be 5.1 mg/kg (2.3 mg/lb). Mean (± SD) induction time was 23.2 ± 4.7 seconds. Apnea was observed in 27 of 28 goats; mean (± SD) duration of apnea was 72.9 ± 38.3 seconds. Dose did not correlate with duration of apnea. Myoclonic activity was observed in 16 of 28 goats; frequency of myoclonus was not associated with dose. Cyanosis, regurgitation, and signs of pain during injection were not observed.
Clinical Implications—
Administration of propofol at 5.1 mg/kg (2.3 mg/lb), IV, should permit endotracheal intubation in half of unpremedicated, healthy, mature goats. Myoclonus and apnea were associated with propofol administration. (J Am Vet Med Assoc 1997;211:86–88)
Abstract
Objective
Sedative, cardiorespiratory, and analgesic effects of intramuscular administration of medetomidine (40 µg/kg of body weight)-glycopyrrolate (0.01 mg/kg) and medetomidine (10 µg/kg)-butorphanol (0.2 mg/kg)-glycopyrrolate (0.01 mg/kg) combinations were compared. Additional evaluations were done on reversal of medetomidine, using atipamezole (200 µ g/kg, IV), after 90 minutes of medetomidine-induced sedation.
Design
Crossover study, with each dog receiving each drug combination at 1-week intervals.
Animals
Six 2-year-old English hound-type dogs.
Procedure
Arterial blood pressure, ECG, respiratory rate, tidal volume, minute volume, arterial blood gas tensions, and serum biochemical variables were measured before, during, and after sedation. Analgesia was evaluated by needle prick on the skin and tail clamp.
Results
Heart rate decreased significantly from 100 beats/mm to <40 beats/min within 3 minutes of injection of medetomidine and medetomidine. and butorphanol (MB). Mean arterial blood pressure in both groups were maintained above 100 mm of Hg throughout the recording period. There was no significant difference between medetomidine and MB in respiratory rate, tidal volume, and minute ventilation. Hypoxemia (PaO2 < 60 mm of Hg) was observed at 10 and 20 minutes in 2 dogs given MB. Atipamezole administration in the dogs given medetomidine significantly increased PaO2 and returned the values to baseline. Needle prick analgesia duration was longer in the medetomidine (80 ± 7.7 minutes) than MB (56.0 ± 19.2 minutes) group. Tail pinch analgesia was variable in both groups. Duration of lateral recumbency was longer after medetomidine (90 ± 0 minutes) than MB (73.5 ± 19.0 minutes).
Conclusion
Medetomidine and MB were effective combinations for mildly invasive procedures.
Clinical Relevance
MB induced a shorter period of analgesia and recumbency than did medetomidine. (Am J Vet Res 1996;57:535–540)
