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To determine response rate and remission as well as survival times for dogs with multicentric lymphoma treated first with doxorubicin alone or in combination with asparaginase and then with cyclophosphamide, vincristine sulfate, and prednisone (CVP) and to identify prevalence of toxicoses associated with this protocol and factors associated with prognosis.


Retrospective case series.


121 dogs.


Variables evaluated for prognostic value were initial response rate to chemotherapy, age, breed, sex, body weight, histologic grade, clinical stage and substage, previous corticosteroid treatment, and serum calcium concentration.


Median overall remission and survival times for all 121 dogs were 205 and 237 days, respectively. Response rate (complete or partial response) was 88%. Ten dogs were hospitalized because of toxicoses associated with doxorubicin, and 19 dogs were hospitalized because of toxicoses associated with CVP. Asparaginase favorably influenced the initial response rate, but did not significantly influence overall remission or survival times. Initial response rate to chemotherapy, body weight. clinical substage, and serum calcium concentration was found to have prognostic value.

Clinical Implications

For dogs with multicentric lymphoma, treatment with doxorubicin alone or in combination with asparaginase and then with CVP resulted in an acceptable response rate and low prevalence of toxicoses. (J Am Vet Med Assoc 1997;210:512–516)

Free access
in Journal of the American Veterinary Medical Association



To determine how long serum concentrations of ω-3 fatty acids remain elevated after cessation of dietary fish oil supplementation.


12 healthy Beagles.


Baseline serum concentrations of linoleic acid, linolenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were measured. Dogs were then fed a diet supplemented with soybean oil or fish oil for 8 weeks, and serum fatty acid concentrations were measured while dogs were fed the experimental diets and for 18 weeks after they were switched to a maintenance diet.


For dogs fed the fish oil diet, serum EPA and DHA concentrations were significantly increased by week 1 and remained increased for 7 (DHA concentration) or 3 (EPA concentration) weeks after dietary fish oil supplementation was discontinued.


In dogs, supplementation of the diet with fish oil may have effects for several weeks after dietary supplementation is discontinued.

Clinical Relevance

Studies of the effects of fish oil supplementation that use a crossover design should allow for an appropriate washout period. (Am J Vet Res 1998;59:864–868)

Free access
in American Journal of Veterinary Research