Objective—To evaluate the tensile strength, elongation,
and degradation of 4 monofilament absorbable
suture materials that undergo degradation by hydrolysis
in specimens of canine urine with various physical
Procedure—Voided urine was collected from 6
healthy dogs, pooled, filter-sterilized, and prepared to
provide 5 media: sterile neutral (pH, 7.0), sterile acidic
(pH, 6.2), sterile basic (pH, 8.8), Escherichia coli-inoculated,
and Proteus mirabilis-inoculated urine. Ten
strands of each suture material were immersed in
each of the media for 0 to 28 days. Tensile strength
and elongation of each suture material were evaluated
by use of a texture analyzer on days 0, 1, 3, 7, 10,
14, 21, and 28.
Results—Reduction in tensile strength was detected
for all materials in all urine specimens over time.
Polyglyconate and polydioxanone had superior tensile
strengths in sterile neutral and E coli-inoculated urine,
and polydioxanone retained the greatest tensile
strength throughout the study period. All suture materials
disintegrated before day 7 in P mirabilis-inoculated
Conclusions and Clinical Relevance—Polydioxanone, polyglyconate, and glycomer 631 may
be acceptable for urinary bladder closure in the presence
of sterile neutral and E coli-contaminated urine.
Tensile strength of poliglecaprone 25 in urine may be
unacceptable by the critical healing time for bladder
tissue (14 to 21 days). During bladder surgery, exposure
of suture material that degrades via hydrolysis to
urine containing Proteus spp should be minimized.
Am J Vet Res (2004;65:847–853)