Objective—To evaluate short-term hemodynamic
effects of ecadotril in a model of congestive heart failure
Animals—6 conscious adult male dogs.
Procedures—Instruments were placed in dogs to
measure left ventricular, aortic, and atrial blood pressures.
Heart failure was induced by repeated coronary
embolization with latex microspheres. Four
times, and in random order, dogs were given vehicle
or active drug (3, 10, or 30 mg/kg of body weight) orally.
Hemodynamic variables, urine flow, and urinary
electrolyte excretion were measured before and 30,
90, and 150 minutes, and 10 and 21 hours after drug
Results—Changes in urine flow, heart rate, mean
arterial pressure, or peak positive and negative rate of
change in ventricular pressure were not apparent.
Urinary sodium excretion significantly increased in
response to the low and high doses of ecadotril but
not in response to the 10 mg/kg dose. Left ventricular
end diastolic pressure (LVEDP) consistently
decreased in dose- and time-dependent manner.
Maximal group-averaged reductions in LVEDP were
5.2, 8.1, and 10 mm Hg for the low, middle, and high
doses, respectively. The magnitude of the decrease
in LVEDP was not related to cumulative change in
Conclusions and Clinical Relevance—Orally
administered ecadotril reduced left ventricular filling
pressures in these dogs by a mechanism that does
not require a substantial diuretic effect. Ecadotril
may be effective for alleviating clinical signs in dogs
with left-sided heart failure and may be particularly
beneficial for use in dogs that are refractory to traditional
diuretic therapy. (Am J Vet Res 2000;61: