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. The mesenchymal stromal cells (MSCs) derived from adipose tissue (ASCs) or placenta (PMSCs) belong to the most frequently used proregenerative and immunomodulatory pool in the clinical practice of the stromal cells. Work completed over the past decade

Open access
in Journal of the American Veterinary Medical Association

F eline mesenchymal stem cells (MSCs; sometimes referred to as mesenchymal stromal cells) were first mentioned in the literature in 2002. 1 Significant interest has been placed on the potential of MSC and related animal cell and tissue

Open access
in Journal of the American Veterinary Medical Association

analysis using Microsoft Excel and GraphPad Prism 10. Results Available articles PUBMED search terms included ((feline) AND ((stem cell) OR (stromal cell) OR (stromal vascular fraction))), which resulted in 1,664 articles. A filter was applied

Open access
in Journal of the American Veterinary Medical Association

. Lacy Kamm, Assistant Professor of Large Animal Surgery, is investigating the use of autologous and allogeneic mesenchymal stromal cells in the treatment of degenerative, inflammatory conditions including osteoarthritis, tendonitis, and desmitis in

Open access
in American Journal of Veterinary Research

tissue, and a limited reparative magnitude of articular cartilage in joints. Regenerative medicine aims to heal and restore normal aspects of the tissue affected by using scaffolds, growth factors, or cell-based therapies. 5 Mesenchymal stromal cells

Open access
in American Journal of Veterinary Research

-immunogenicity balance, cell viability, and differentiation potential . Stem Cells Dev . 2017 ; 26 ( 1 ): 15 – 24 . doi: 10.1089/scd.2016.0209 13. Le Blon D , Hoornaert C , Detrez JR , et al . Immune remodelling of stromal cell grafts in the central nervous

Open access
in Journal of the American Veterinary Medical Association

enhance MSC function and subsequently, tendon healing. 5 , 64 , 65 Modulation of endogenous and retention of exogenous stromal cells Endogenous stromal cells, primarily those of tenocytes and TSPCs are a key cell population of the tendon

Open access
in American Journal of Veterinary Research

. Guest DJ , Smith MRW , Allen WR . Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendon . Equine Vet J

Open access
in Journal of the American Veterinary Medical Association

migration translates to the in vivo environment, it may confer benefits to the healing tendon, especially in the early stages of injury following the loss of endogenous stromal cell populations. 30 Following injury, tendon tissue undergoes stages of

Open access
in Journal of the American Veterinary Medical Association

The Confusing Landscape of Mesenchymal Stromal Cell Therapies Mesenchymal stromal cells (MSCs) have been demonstrated in numerous studies to aid in bone repair, 1 skeletal muscle regeneration, 2 – 4 and cartilage regeneration. 5 While MSCs

Open access
in Journal of the American Veterinary Medical Association