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tendon injuries. Figure 1 Licensing strategies to improve the effector function of naïve mesenchymal stem cells (MSCs). Created with BioRender.com. Effector Function of Licensed MSCs Innate immune cell modulation Immune cells of both

Open access
in American Journal of Veterinary Research

. For all these reasons, novel therapies to improve tendon healing and reduce failure and reinjury rates are needed. The purpose of this manuscript is to review the evidence available for the use of mesenchymal stem cells (MSCs) to improve tendon healing

Open access
in Journal of the American Veterinary Medical Association

T here remains a critical need to more thoroughly elucidate the mesenchymal stem cell (MSC) mechanism of action to improve their utilization as a cellular therapy. This is apparent in recent research, which has steered a paradigm shift toward

Open access
in Journal of the American Veterinary Medical Association

(EVs) released from mesenchymal stem cells (MSCs) are responsible for many of the bioactive properties of the cells. These EVs could play a significant role in decreasing inflammation within the joint and reducing the negative effects of inflammatory

Open access
in Journal of the American Veterinary Medical Association

multiple pathologies like renal disease or liver failure. 6 In recent years, mesenchymal stem cells (MSCs) have been postulated as a potential treatment for musculoskeletal disorders and systemic diseases in dogs. 7 , 8 Several publications also support

Open access
in Journal of the American Veterinary Medical Association
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. Subconjunctival bone marrow-derived mesenchymal stem cell therapy as a novel treatment alternative for equine immune-mediated keratitis: a case series . Vet Ophthalmol . 2019 ; 22 ( 5 ): 674 – 682 . doi: 10.1111/vop.12641 30715781 13. Schnabel LV

Open access
in American Journal of Veterinary Research

F eline mesenchymal stem cells (MSCs; sometimes referred to as mesenchymal stromal cells) were first mentioned in the literature in 2002. 1 Significant interest has been placed on the potential of MSC and related animal cell and tissue

Open access
in Journal of the American Veterinary Medical Association

– 560 . doi: 10.5966/sctm.2015-0261 10. Carrade Holt DD , Wood JA , Granick JL , Walker NJ , Clark KC , Borjesson DL . Equine mesenchymal stem cells inhibit T cell proliferation through different mechanisms depending on tissue source

Open access
in Journal of the American Veterinary Medical Association

.3109/17453674.2010.539498 10.3109/17453674.2010.539498 25709479 3. Leroux L , Descamps B , Tojais NF , Hypoxia preconditioned mesenchymal stem cells improve vascular and skeletal muscle fiber regeneration after ischemia through a Wnt4-dependent pathway . Mol

Open access
in Journal of the American Veterinary Medical Association

(aka mesenchymal stem cells or MSCs) are progenitor cells that can be isolated from bone marrow as well as other tissue sources (eg, placenta, adipose) and have demonstrated some positive results as a regenerative medicine treatment of orthopedic

Open access
in American Journal of Veterinary Research