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treat cats with occult HCM. Rapamycin, also known as sirolimus, a macrolide and inhibitor of the mechanistic (previously called mammalian) target of rapamycin (mTOR), shows promise as a novel therapeutic for feline HCM. 5 – 10 mTOR is an atypical

Open access
in Journal of the American Veterinary Medical Association

effects by modulating cytokine production, specifically by downregulating interferon-γ (IFN-γ) and upregulating IL-6 in cells derived from a monocyte cell line when exposed to histamine stimulation. The mammalian target of rapamycin (mTOR), a key regulator

Open access
in American Journal of Veterinary Research

growth hormone (GH) and insulin-like growth factor-1 (IGF-1); insulin and other factors regulating glucose metabolism; mechanistic target of rapamycin (mTOR; a serine/threonine protein kinase, involved in regulation of protein metabolism); and systems

Open access
in American Journal of Veterinary Research

abnormalities via inhibition of mTOR in osteoarthritis . Biomaterials . 2019 ; 206 : 87 – 100 . doi: 10.1016/j.biomaterials.2019.03.022 10.1016/j.biomaterials.2019.03.022 39. Wong KL , Zhang S , Wang M , Intra-articular injections of mesenchymal

Open access
in Journal of the American Veterinary Medical Association

X , Zhang Q . MiR-21 modulates proliferation and apoptosis of human airway smooth muscle cells by regulating autophagy via PARP-1/AMPK/mTOR signalling pathway . Respir Physiol Neurobiol . 2022 ; 301 : 103891 . doi: 10.1016/j.resp.2022

Open access
in American Journal of Veterinary Research

; 7 ( 3 ): 195 – 205 . 8. Colapietro A , Yang P , Rossetti A , The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human glioblastoma, reduces Akt/mTOR activities, and modulates GSC cell

Open access
in Journal of the American Veterinary Medical Association