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negative effects of the disease. Thus, a targeted therapy that could mitigate the inflammatory processes within the joint to prevent damage in the early stages of disease would be very beneficial. Recent studies have suggested that extracellular vesicles

Open access
in Journal of the American Veterinary Medical Association

markers of EVs in a sample. The International Society of Extracellular Vesicles 7 , 8 stated that minimal EV identification and characterization criteria include transmission electron microscopy or scanning electron microscopy size assessment

Open access
in Journal of the American Veterinary Medical Association

variety of medical conditions with varying severity of disease. Taken together, these variables have made it extremely difficult to define the clinical efficacy of SC treatments and develop best practices for their use. 7 Extracellular Vesicles and

Open access
in Journal of the American Veterinary Medical Association

table. Table 2 Differentially expressed plasma and synovial fluid extracellular vesicle microRNAs (miRNAs) with the highest and lowest log2 fold change (LogFC) when comparing horses with PTOA to control horses. Plasma miRNAs LogFC

Open access
in Journal of the American Veterinary Medical Association
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disease control. Her interest in noncoding RNA and extracellular vesicle signaling extends into her studies of cardiovascular toxicity secondary to anticancer treatment in veterinary patients. These noncoding RNAs, especially in the context of their

Open access
in American Journal of Veterinary Research

MSCs secreted paracrine factors and extracellular vesicles can greatly alter macrophage polarization. 23 Prostaglandin E 2 (PGE 2 ), IL-1 receptor antagonist, IL-10, indoleamine 2,3-dioxygenase (IDO), and C-C motif ligand 18, secreted factors from

Open access
in American Journal of Veterinary Research

alternative therapies for human and equine patients. Neutrophils might act as key components of airway dysfunction through the release of various mediators, including extracellular vesicles (EVs). These nanoscale membrane-derived particles are lipid bilayer

Open access
in American Journal of Veterinary Research

a decrease in HA content in extracellular vesicles released by synovial articular cells during natural equine osteoarthritis. Contrary to our results, serum hyaluronic acid was elevated in humans with hand osteoarthritis, but it is a useful

Open access
in American Journal of Veterinary Research

events were reported in 7 of the 10 (70%) cats. The second study used extracellular vesicles excreted from allogeneic adipose-derived MSCs administered once IV to treat postrenal AKI induced through urethral obstruction in 3 cats. 23 The cats were only

Open access
in Journal of the American Veterinary Medical Association

-derived products, such as extracellular vesicles (EVs), are another type of ACTP being investigated for clinical use. To understand the current status of MSCs and MSC product use in cats, a scoping review of the published literature to date was performed. This

Open access
in Journal of the American Veterinary Medical Association