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blood cell lifespan, 7 probably because canine erythrocytes maintain antioxidant defenses in CKD. 8 A considerable proportion of people with CKD are resistant to erythropoiesis-stimulating agents. 5 This resistance is probably the result of

Open access
in American Journal of Veterinary Research

I ron is an essential mineral that is critical to many physiological processes including oxygen transport, DNA synthesis, and energy production. 1 It is also a critical component for erythropoiesis, particularly in the development of

Open access
in American Journal of Veterinary Research

progenitor cell receptors in the bone marrow to stimulate erythropoiesis and increase Hct. In human and veterinary medicine, DPO is commonly given to patients with chronic progressive anemia, including those with anemia secondary to chronic kidney disease

Open access
in American Journal of Veterinary Research

clinically significant nonregenerative anemia. 14 , 15 Anemia secondary to CRD is a result of decreased production of kidney-associated erythropoietin (EPO), the principal hormonal regulator of erythropoiesis. Spliced feline EPO (feEPO) mRNA is 579

Open access
in American Journal of Veterinary Research

, dyserythropoiesis, chronic doxorubicin toxicosis, or oxidative stress. 32 , 37 , 38 , 39 Nevertheless, in the present study, there were no clinical signs suggestive of defective erythropoiesis, no history of previous doxorubicin administration, and no other

Open access
in American Journal of Veterinary Research

increased serum erythropoietin . Eur J Heart Fail . 2010 ; 12 ( 4 ): 354 – 359 . doi: 10.1093/eurjhf/hfq005 42. Vlahakos DV , Marathias KP , Madias NE . The role of the renin-angiotensin system in the regulation of erythropoiesis . Am J Kidney

Open access
in American Journal of Veterinary Research

due to decreases in hemoglobin concentration and erythrocyte mass. 17 There are numerous underlying causes of anemia. The 3 primary mechanisms of anemia are blood loss, destruction of erythrocytes, and decreased erythropoiesis. 17 An Hct measurement

Open access
in American Journal of Veterinary Research