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stirred bioreactors, which can be scaled up (> 100 L) for manufacturing purposes. 9 The use of microcarrier-based 3-D culture has been demonstrated to improve MSC expansion efficiency in equine MSCs. 10 , 11 In addition to improving MSC culture

Open access
in Journal of the American Veterinary Medical Association

chemosensitivity to carboplatin. We hypothesized that IC 50 values of carboplatin against FISAS and FOSCC cells measured at 72 hours in 3-D culture would fall within the range of carboplatin concentrations known to elute from C-ICSH beads over the same time period

Open access
in American Journal of Veterinary Research

in vitro results to in vivo environments. 45 In contrast to monolayer cultures, 3-D cultures better develop in vivo characteristics including cellular morphologies, structural organization, intercellular interactions, and gene expression patterns. 46

Open access
in American Journal of Veterinary Research