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dogs was accomplished by soliciting participation via veterinarians (veterinary oncologists) and owners. Samples were submitted from the Washington State University College of Veterinary Medicine; Veterinary Oncology Services PLLC, Hopewell Junction, NY

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in American Journal of Veterinary Research

-term adverse effects. Short-term adverse effects were defined as any adverse clinical sign that developed during the 7-day period of G-CSF administration, as detected by the dogs' owners and a veterinarian who performed a physical examination the day after the

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in American Journal of Veterinary Research

obtained from referring veterinarians and clients. Acute adverse events were defined as treatment-associated complications occurring within 90 days of SRS. 32 Late (delayed) adverse events were defined as treatment-associated complications occurring > 6

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in American Journal of Veterinary Research

veterinarians discontinue or extend the dosing interval of the drug, although no definitive guidelines have been established. Dogs treated with lomustine commonly receive glucocorticoids concurrently for the treatment of hematopoietic malignancies, and

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in American Journal of Veterinary Research

, at least anecdotally, veterinarians have been reluctant to include morphine as part of an anesthesia protocol for MCT excision; yet, no data that support their reluctance have been published. Morphine-induced histamine release from mast cells does

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in American Journal of Veterinary Research

appetite, and lethargy. Adverse events were evaluated by a veterinarian by use of a scale that corresponded with criteria developed by the Veterinary Cooperative Oncology Group. 18 Adverse events were graded on a scale that ranged from 0 (none) to 4 (life

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in American Journal of Veterinary Research

abdominal radiography, and abdominal ultrasonography by use of the WHO staging criteria. 22 Written consent was obtained from all dog owners prior to study enrollment. Evaluation of response to treatment —Veterinarians measured the size of the enlarged

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in American Journal of Veterinary Research

records were reviewed. If needed, additional information was obtained through a questionnaire distributed to the referring veterinarians to verify information regarding date of diagnosis and death as well as cause of death or reason for euthanasia. MI

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in American Journal of Veterinary Research

in this category because of the owners' lack of adherence to the follow-up examination schedule; and monitoring of 1 dog was taken over by the owner and primary care veterinarian. Nine dogs were removed from the study (7 to pursue alternate treatments

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in American Journal of Veterinary Research

complete remission or progressive disease was detected. Treatment with EC0905 was discontinued in dogs with progressive disease, but these dogs were provided rescue chemotherapy at the discretion of the owner and attending veterinarian. Treatment

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in American Journal of Veterinary Research