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calculated to provide the overall percentage of tumor shrinkage in each dimension or volume. For each tumor, the ellipsoid volume was calculated as (length × width × depth) × (π/6). A Student paired t test was used to compare normalized ex vivo

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in American Journal of Veterinary Research

client-owned dogs that were admitted to the University of Illinois Veterinary Teaching Hospital for diagnosis and treatment of other disorders or were student-owned dogs that were clinically normal. Control dogs that were admitted for other conditions

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in American Journal of Veterinary Research

with Tukey post hoc comparisons, with α set at P = 0.05. Results of cytotoxicity testing that compared lycopene alone with lycopene and doxorubicin were analyzed at each lycopene concentration by use of a nonpaired Student t test, with α set at P

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in American Journal of Veterinary Research

comparisons test. Proliferation rates of MDA-1986 cells exposed to cisplatin or HA-Pt were analyzed by nonlinear regression, and mean ± SEM IC 50 s were compared between treatments by use of a Student t test. A 2-way ANOVA followed by a Sidak test for

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in American Journal of Veterinary Research

. Acknowledgments Supported in part by the Merial Veterinary Scholars Program and Students Training in Advanced Research. The authors thank Dr. George Brewer, University of Michigan, for providing the TM. ABBREVIATIONS MTS (3-(4,5-dimethylthiazol-2-yl

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in American Journal of Veterinary Research

docetaxel/kg) were evaluated by 1-variable ANOVA. Further comparisons of pharmacokinetic variables among dogs in the 1.75 mg/kg dose group and healthy dogs evaluated in the earlier study 8 were made by use of an unpaired Student t test. Values of P < 0

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in American Journal of Veterinary Research

calculated for each cell line. Analysis was performed with the aid of a computer software package. o A 1way ANOVA was used for comparison of means, followed by the Student t test analysis between pairs, to identify groups significantly different from the

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in American Journal of Veterinary Research

hemangiosarcoma tissue and hemangiosarcoma serum samples. A Student t test was used to compare miRNA expression between control tissue and hemangiosarcoma tissue samples. Serum miRNA expression among the 3 groups (control, hemangiosarcoma, hematoma) was compared

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in American Journal of Veterinary Research

treatment (none vs surgery), sex (male vs female), ifosfamide-associated neutropenia (yes vs no), and ifosfamide-associated gastrointestinal toxicosis (yes vs no). Student t tests were used for analyses of continuous data that were normally distributed

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in American Journal of Veterinary Research

Tukey multiple comparisons post hoc analyses and Student t tests were used where appropriate. Normal distribution of data was determined via visual analysis of frequency distribution graphs. Values of P < 0.05 were considered significant

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in American Journal of Veterinary Research