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, growth factor-binding proteins and growth factor precursors, receptor tyrosine kinases, cell adhesion molecules, and other proteases. 17 Thus, MMPs are instrumental in the molecular crosstalk between tumor and stromal cells. 18 The exact location of

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in American Journal of Veterinary Research

has been suggested that both tumor and stromal cell components may cooperate, which enables tumor cells to reach their target organ and survive the metastatic process. 3,7–9 Thus, MMP-2 and -9 in tumor stromal elements has been reported in several

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in American Journal of Veterinary Research

versican is predominantly incorporated and accumulated into the hyaluronan matrix surrounding stromal cells. Thus, hyaluronan produced endogenously by tumor and stromal cells may support compartmentalization of versican on the cell surface. Because of the

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in American Journal of Veterinary Research

-L1 (eg, tumor cells, tumor-infiltrating lymphocytes, or stromal cells), the percentage of PD-L1–expressing cells, and the localization of PD-L1 within those cells would have been a useful complement to the qPCR assay described in this study

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in American Journal of Veterinary Research

epithelial cells; its ligand, HGF, is primarily produced by stromal cells. 35,36 Interactions of Met and HGF promote an array of cellular responses, such as proliferation, scattering (motility), and branching morphogenesis, which are all important in normal

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in American Journal of Veterinary Research