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study 25 found alteration of miRNA expression in the splenic tissue among dogs with histologically normal spleens, dogs with hemangiosarcoma, and those with splenic nodular hyperplasia. The objective of the present study was to identify miRNAs that

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in American Journal of Veterinary Research

-needle aspirate samples from the liver or spleen of lymphoma-affected dogs have not been reported. Investigators of previous studies 24–26 used flow cytometry to evaluate tissue samples obtained from the liver or spleen of dogs via biopsy or necropsy. The

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in American Journal of Veterinary Research

JPG file format and imported into image analysis software. b Regions of interest were drawn around the peripheral (mandibular, superficial cervical, and popliteal) lymph nodes, liver, and spleen. The intensity of these regions, determined with

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in American Journal of Veterinary Research

basis of a spleen abscess and resultant septic peritonitis. The study was stopped and further recruitment was discontinued because the starting dose remained above or equal to the MTD. The most common acute toxic effect detected was fever, which was

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in American Journal of Veterinary Research

range at all times. 19 Redirection of hematopoiesis to neutrophil production and the development of extramedullary hematopoiesis in the liver and spleen were speculated mechanisms of this delayed-onset thrombocytopenia. 19 Fifteen dogs in the present

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in American Journal of Veterinary Research

heart, lungs, liver, kidneys, spleen, pancreas, and duodenum from each mouse were fixed in neutral-buffered 10% formalin and processed routinely for H&E staining and histologic evaluation. Plasma from each mouse was frozen for biochemical analysis. The

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in American Journal of Veterinary Research

Hemangiosarcoma is a malignant tumor of endothelial cells that commonly arises from the spleen, heart, liver, and subcutis in dogs, accounting for 7% of all canine malignant tumors. 1–4 Such tumors are extremely aggressive owing to their high

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in American Journal of Veterinary Research

revealed a subjectively small liver that was subjectively hyperechoic but hypoechoic relative to the spleen. The portal vessels appeared thickened and irregular. Ascites was not observed. The dog was withdrawn from the study on day 41, treated with a

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in American Journal of Veterinary Research

obtained from a dog with terminal mast cell disease with recurrence of the primary tumor and distant metastasis to the liver, spleen, lymph nodes, and bone marrow. Biopsy specimens were obtained from a recurrent subcutaneous MCT at the primary site. The C2

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in American Journal of Veterinary Research

intermediate to high grade in nature and have a multicentric anatomic distribution in which peripheral lymph nodes are primarily affected, with secondary involvement of the liver, spleen, bone marrow, and other organs. Standard treatment for these cancers

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in American Journal of Veterinary Research