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. In dogs, the spleen has the greatest capacity to release blood into the circulation, which causes a local elevation in viscosity. 18–20 The splenic vein contributes a large portion of blood to the PV. 19 It is possible this local increase in

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in American Journal of Veterinary Research

of the mononuclear phagocyte system, which are primarily located in the spleen, recognize aged erythrocytes and remove them from circulation. Multiple theories exist regarding the erythrocyte changes that trigger this recognition and removal, and

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in American Journal of Veterinary Research
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17. Grimes JA Prasad N Levy S , et al. A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs . BMC Vet Res 2016 ; 12 : 272 – 284 . 10.1186/s12917-016-0903-5 18

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in American Journal of Veterinary Research