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Bovine respiratory disease complex is the most common and expensive disease of feedlot cattle in the United States, 1–3 accounting for approximately 50% of the morbidity rate and > 75% of deaths. 4 It has been estimated that BRDC results in

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in American Journal of Veterinary Research

costs, reduced animal performance, and death from BRDC. 4–6 Bovine respiratory disease complex is a multifactorial syndrome caused by environmental factors, management practices, animal susceptibility, and viral and bacterial pathogens. 6 Results of

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in American Journal of Veterinary Research

syndrome (sometimes colloquially referred to as shipping fever in horses) that includes respiratory disease (eg, pneumonia or pleuropneumonia) caused by bacterial infection after long-distance transportation and can potentially increase mortality rate. 1

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in American Journal of Veterinary Research

Respiratory tract disease, particularly pneumonia, is the primary cause of morbidity and economic losses in beef cattle, and it is second only to diarrheal diseases as a cause of morbidity and economic losses in dairy calves. 1,2 Bovine

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in American Journal of Veterinary Research

Gamithromycin is a novel azalide antimicrobial that has recently been developed for the treatment and prevention of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida , and Histophilus somni . Azalides are similar

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in American Journal of Veterinary Research

Eradication of bacteria from the respiratory tract is necessary for a successful clinical outcome in humans with bacterial respiratory infections 1 and is likely necessary in veterinary species as well. Mannheimia haemolytica is the most

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in American Journal of Veterinary Research

-positive, gram-negative, and anaerobic bacteria and is generally resistant to β-lactamases. A crystalline-free acid formulation of ceftiofur suspended in a caprylic-capric triglyceride and cottonseed oil base has been developed for the treatment of respiratory

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in American Journal of Veterinary Research

treatment and prevention of respiratory disease in swine and cattle. Success of tulathromycin for use in treating respiratory diseases may be attributed, at least in part, to its preferential accumulation within pulmonary tissues. 18,32 This antimicrobial

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in American Journal of Veterinary Research

antimicrobial use guidelines for specific conditions exist, then inappropriate use can be identified. For example, appropriateness of antimicrobial use has been assessed in dogs and cats with urinary tract infections or respiratory disease, 13,19 for which

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in American Journal of Veterinary Research

% (ie, free plasma concentration greater than the MIC for at least 10 hours during a 24-hour period) is predictive of appropriate clinical efficacy. 10 For amoxicillin, Schwarz et al 2 suggested a breakpoint in pigs for respiratory tract pathogens. To

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in American Journal of Veterinary Research