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product for treatment of septic arthritis in those species would be advantageous. Platelet-rich plasma (PRP) is an autologous solution of concentrated platelets that contain anabolic and anti-inflammatory proteins or peptides. In veterinary medicine, PRP

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in American Journal of Veterinary Research

,37–40 Autologous PRP has been used as a treatment for osteoarthritis, 41,42 but it can also be coadministered with MSCs or SVF. Platelet-rich plasma contains several growth factors, including vascular endothelial growth factor, platelet-derived growth factor

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in American Journal of Veterinary Research

Lipopolysaccharide NADPH Reduced form of nicotinamide adenine dinucleotide phosphate PG Prostaglandin PMA Phorbol 12-myristate 13-acetate PRP Platelet-rich plasma ROS Reactive oxygen species TNF Tumor necrosis factor Footnotes a. IRAP II system

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in American Journal of Veterinary Research

promising therapeutic strategy. 21 In vitro, PRP induces chondrogenesis by stimulating proliferation of chondrocytes and extracellular matrix synthesis of proteoglycans and type II collagen. 22 Platelet-rich plasma could also induce chondroprotection by

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in American Journal of Veterinary Research

factors, including transforming growth factor-β and platelet-derived growth factor in platelet-rich plasma, 22 and concentrated bone marrow would be anticipated to have similar increases in growth factors. Further work is needed to confirm this for

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in American Journal of Veterinary Research

. i. Olympus America, Center Valley, Pa. References 1. Canapp SO Jr Canapp DA Ibrahim V , et al. The use of adipose-derived progenitor cells and platelet-rich plasma combination for the treatment of supraspinatus tendinopathy in 55

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in American Journal of Veterinary Research

LY Mehta P Mehta JL . Platelet inhibitory effect of nitroglycerin in platelet-rich plasma: relevance of glutathione-s-transferases in plasma . J Investig Med 1996 ; 44 : 561 – 565 . 29. Guzey M Vural H Satici A , et al

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in American Journal of Veterinary Research

currently used in human medicine, injection of platelet-rich plasma and transplantation of stem cells are routinely used to treat orthopedic conditions in horses. Some horses can be maintained via a combination of therapeutic approaches, but osteoarthritis

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in American Journal of Veterinary Research