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Summary

Twenty-nine pruritic, atopic dogs were entered into a double-blind, placebo-controlled, crossover study to evaluate the efficacy of an investigational antiallergenic compound, AHR-13268. Fourteen dogs were evaluated by a veterinary dermatologist (at intervals) and the owner (daily). Fifteen dogs were evaluated only by the owner. The mean (± se) owner scores for pruritus, erythema, and lesions with placebo treatment (higher score = worse signs) were 3.24 (± 0.12), 2.73 (± 0.12), and 2.61 (± 0.09), respectively. With drug treatment, the corresponding scores were 2.89 (± 0.12), 2.50 (± 0.12), and 2.25 (± 0.09). Scores for pruritus and lesions (but not erythema) were significantly better with drug treatment than with placebo treatment. Investigator scores showed similar trends, but the differences were not great enough to be statistically significant. Overall, 11/29 (38%) owners reported their dogs had moderate or better improvement from drug capsules, and 4/29 dogs (14%) improved on placebo capsules A variety of adverse effects were reported following both drug (9/29 dogs) and placebo (8/29 dogs) capsule administration, but were mild and well tolerated. Results of this study indicate that AHR-13268 has potential for empiric treatment of allergic inhalant dermatitis in some dogs.

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in American Journal of Veterinary Research

Pet birds commonly develop behavior problems, with as many as 71% of pet-bird owners reporting that their birds display abnormal behavior and 36% of those owners considering the abnormal behavior problematic. 1 Behavior modification associated

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in American Journal of Veterinary Research