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that studying naturally occurring cancer in privately owned dogs may provide results that are more clinically applicable to human oncology than are results obtained from studies of induced tumors in laboratory animal species. A phase I study of C

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in American Journal of Veterinary Research

search of the medical records at Perth Veterinary Oncology was performed to identify dogs with lymphoma that underwent intensified chemotherapy and received autologous BMT, following administration of recombinant human G-CSF a ( Appendix ). Dogs were

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in American Journal of Veterinary Research

Medicine and the Harrington Oncology Program at Tufts University School of Veterinary Medicine. The study protocol was approved by an institutional animal care and use committee at each institution, and written informed consent was obtained from all clients

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in American Journal of Veterinary Research

evaluated by the facility's oncology service, and had a histologically confirmed diagnosis of anal gland adenocarcinoma, sarcoma, oral SCC, oral melanoma, nasal SCC, or digital SCC were considered for enrollment. Dogs with metastatic cancers were excluded

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in American Journal of Veterinary Research

vaccinate group at 5 specialty oncology practices in various geographic locations in the United States. These included Animal Medical Center, New York; North Carolina State University College of Veterinary Medicine, Raleigh, NC; Southwest Veterinary Oncology

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in American Journal of Veterinary Research

Institute Inc, Cary, NC. h. JMP, version 7.0.1, SAS Institute Inc, Cary, NC. References 1. Dernell WS Straw RC Withrow SJ . Tumors of the skeletal system . In: Withrow SJ MacEwen EG , eds. Small animal clinical oncology . 3rd ed

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in American Journal of Veterinary Research

dogs was accomplished by soliciting participation via veterinarians (veterinary oncologists) and owners. Samples were submitted from the Washington State University College of Veterinary Medicine; Veterinary Oncology Services PLLC, Hopewell Junction, NY

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in American Journal of Veterinary Research

the Veterinary Cooperative Oncology Group, the scoring system approximated this same system, with the exception that it did not contain a score of 5, designated in the Veterinary Cooperative Oncology Group system as the score for death as an adverse

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in American Journal of Veterinary Research

development or recurrence, compared with those who are administered other immunosuppressive agents such as cyclosporine. 4 In human oncology, rapamycin and its derivatives are being used as antineoplastic agents with increasing frequency and have been

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in American Journal of Veterinary Research

. References 1. Dernell WS Ehrhart NP Straw RC , et al. Tumors of the skeletal system . In: Withrow SJ Vail DM , eds. Withrow and MacEwen's small animal clinical oncology . 4th ed. St Louis : Saunders Elsevier , 2007 ; 540 – 582 . 2

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in American Journal of Veterinary Research