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Abstract

Objective—To determine whether passive transfer of IgG in neonatal kittens affects plasma opsonic capacity and neutrophil phagocytic and oxidative burst responses to bacteria in vitro.

Animals—22 kittens from 6 specific pathogen-free queens.

Procedure—Kittens were randomized at birth into the following treatment groups: colostrum-fed, colostrum-deprived, or colostrum-deprived supplemented with feline or equine IgG. Blood samples were collected at intervals from birth to 56 days of age. Plasma IgG concentrations were determined by radial immunodiffusion assay. Neutrophil function was assessed by a flow cytometry assay providing simultaneous measurement of bacteria-induced phagocytosis and oxidative burst. The opsonic capacity of kitten plasma was determined in an opsonophagocytosis assay with bacteria incubated in untreated or heat-inactivated plasma.

Results—Among treatment groups, there were no significant differences in neutrophil phagocytic and oxidative burst responses to bacteria or opsonic capacity of plasma. In all samples of plasma, inactivation of complement and other heat-labile opsonins significantly reduced the opsonic capacity. Plasma IgG concentrations in kittens did not correlate with neutrophil function or plasma opsonic capacity before or after inactivation of complement.

Conclusions and Clinical Relevance—The plasma opsonic capacity and neutrophil phagocytic and oxidative burst responses in vitro of kittens receiving passive transfer of IgG via colostrum intake or IgG supplementation and those deprived of colostrum were similar. The alternate complement pathway or other heat-labile opsonins may be more important than IgG in bacterial opsonization and phagocytosis. ( Am J Vet Res 2003;64:538–543)

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in American Journal of Veterinary Research

Plant Health Inspection Service announced that the vaccine against the porcine epidemic diarrhea virus is intended to generate antibody production in sows, which transmit antibodies through milk to neonatal pigs. It is the first USDA-licensed vaccine

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in American Journal of Veterinary Research

, University of Georgia, for “Hypothalamic-pituitaryadrenal axis dysfunction in critically ill neonatal foals”; Gastroenterology— Dr. Kelly Gingerich, Purdue University, for “Serum zinc and magnesium concentrations in dogs with inflammatory bowel disease

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in American Journal of Veterinary Research

student awards were as follows: Epidemiology and Animal Health Economics category, oral —Matthew Allerson, University of Minnesota, for “The impact of maternally derived immunity on influenza virus transmission in neonatal pig populations,” and Heidi

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in American Journal of Veterinary Research

-level clinical services for small and large animals as well as accommodate diagnostic services in the areas of pathology, microbiology, parasitology, virology, and immunology. Other new features include a dog park, covered equine lameness arena, equine neonatal

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in American Journal of Veterinary Research

Guelph, for “Age-dependent variation in the expression of CD21, CD32, and mIgM in the lymphoid tissues of calves.” Third place, oral—M.A. Firth, University of Guelph, for “Expression profiles of bovine neonatal B cells determined by quantitative multiplex

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in American Journal of Veterinary Research

her new home in Florida. Minnie began to show signs of an early delivery and was taken to the University of Florida College of Veterinary Medicine for observation and intervention. That's where Mouse arrived and was cared for by a team of neonatal

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in American Journal of Veterinary Research

University, for “The effect of maternal colostral immune cells on neonatal health and immune development.” Second place, poster —Anne Johnson, Virginia Tech, for “ Staphylococcus aureus inhibition of dendritic cell apoptosis.” Third place, poster —Mari

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in American Journal of Veterinary Research