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zoster ophthalmicus, herpes simplex keratitis, and brainstem neurologic disease or trauma. 10 A correlation between corneal sensitivity and systemic illness has been identified in neonatal foals. 11 Corneal sensitivity is reduced in dogs with diabetes

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in American Journal of Veterinary Research

of ocular importance, including HSV-1, HSV-2, varicella-zoster virus, FHV-1, and BHV-1. 2,3 Clinical disease manifestations and severity during primary infection with these viruses, including CHV-1, are age dependent. Fetal and neonatal primary

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in American Journal of Veterinary Research

Canine herpesvirus-1 is a varicellovirus of the subfamily Alphaherpesvirniae. 1 The virus was first identified in the 1960s as an agent that causes systemic infections in neonatal dogs. 2 The ocular disease associated with fetal and neonatal

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in American Journal of Veterinary Research

.2460/ajvr.2003.64.7 14. Brooks DE Clark CK Lester GD . Cochet-Bonnet aesthesiometer-determined corneal sensitivity in neonatal foals and adult horses . Vet Ophthalmol 2000 ; 3 : 133 – 137 . 10.1046/j.1463-5224.2000.00125.x

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in American Journal of Veterinary Research

transport to regional sensory ganglia, where it establishes latency. 2 Depending on the specific canine population evaluated, 39% to 93% of dogs are latently infected with CHV-1. 3–8 Historically, CHV-1 was primarily regarded as a pathogen of neonates

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in American Journal of Veterinary Research

.64.7 9. Brooks DE Clark CK Lester GD . Cochet-Bonnet aesthesiometer-determined corneal sensitivity in neonatal and adult horses . Vet Ophthalmol 2000 ; 3 : 133 – 137 . 10.1046/j.1463-5224.2000.00125.x 10. Trost K Skalicky M Nell

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in American Journal of Veterinary Research

: 1576 – 1577 . 10.2460/javma.2000.216.1576 15. da Silva EG , Sandmeyer LS , Gionfriddo JR . Tear production in canine neonates—evaluation using a modified Schirmer tear test . Vet Ophthalmol 2013 ; 16 : 175 – 179 . 10.1111/j.1463

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in American Journal of Veterinary Research

ophthalmic survey of the neonatal horse . Equine Vet J Suppl 1983 ; 2 : 9 – 14 . 12. Lavach JD . Large animal ophthalmology . St Louis : Mosby Co , 1990 ; 101 – 102 . 13. Miller TL Willis AM Wilkie DA , et al. Description of ciliary

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in American Journal of Veterinary Research

. Permeability of iridial blood vessels . Exp Eye Res 1975 ; 21 : 531 – 543 . 40. Bellhorn RW . Permeability of blood-ocular barriers of neonatal and adult cat to sodium fluorescein . Invest Ophthalmol Vis Sci 1980 ; 19 : 870 – 877 . 41. May CA

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in American Journal of Veterinary Research

. Ophthalmic Physiol Opt 1988 ; 8 : 215 – 220 . 10.1111/j.1475-1313.1988.tb01040.x 46. Wiesel TN Raviola E . Myopia and eye enlargement after neonatal lid fusion in monkeys . Nature 1977 ; 266 : 66 – 68 . 10.1038/266066a0 47. Yinon U Rose

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in American Journal of Veterinary Research