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Minimum inhibitory concentration t max Time to reach peak plasma doxycycline concentration a. Hapasil, Intervet Schering-Plough, Bowmeer, The Netherlands. b. Syvadox-10 (10% doxycycline hyclate), Syva Laboratories, León, Spain. c. Venoject

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in American Journal of Veterinary Research

-life λ Slope of the terminal phase AUC 0-12 AUC from 0 to 12 hours AUC 0-∞ AUC extrapolated to infinity MIC 90 Minimum inhibitory concentration-90% a. Doxycycline hyclate tablets, 500 mg, West-ward Pharmaceutical Corp

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in American Journal of Veterinary Research

absorbed C MAX Observed maximum plasma concentration λz Plasma terminal rate constant MIC Minimum inhibitory concentration T 1/2 Terminal half-life T MAX Time to reach maximum plasma concentration Footnotes a. Mazuri Rodent Breeder 6F

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in American Journal of Veterinary Research

Plaster of Paris SIS Small intestinal submucosa MIC Minimum inhibitory concentration TDR Total amount of drug released at infinity TDR t50 Time needed for the cumulative drug release to reach 50% of TDR γ Curvature

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in American Journal of Veterinary Research

Maximum plasma concentration PK-PD Pharmacokinetic-pharmacodynamic MIC Minimum inhibitory concentration a. Vfend IV, package insert, Pfizer Ltd, Sandwich, UK. b. Vfend IV, Pfizer Ltd, Sandwich, UK. c. Pfizer Ltd, Global Research

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in American Journal of Veterinary Research

–∞ /dose of CCFA) were determined for each dose for each hawk. Points at which plasma concentrations of CFAEs were higher than the MIC of ceftiofur were also determined. MIC determination Minimum inhibitory concentrations of ceftiofur were

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in American Journal of Veterinary Research

exceeded the minimum inhibitory concentration (MIC) against N guarroi and be safe in bearded dragons. Materials and Methods Animals This study was carried out with the approval of the University of Illinois Institutional Animal Care and Use

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in American Journal of Veterinary Research
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needed. ABBREVIATIONS AUC Area under the time-concentration curve AUC:MIC Ratio of the area under the time-concentration curve to the minimum inhibitory concentration BCS Biopharmaceutics Classification System Cmax Maximum (peak

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in American Journal of Veterinary Research

criterion CV Coefficient of variation F Bioavailability FOCE First-order conditional estimate Ke Elimination constant Kel Elimination rate constant LL Log likelihood value MIC Minimum inhibitory concentration Vd Volume of distribution

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in American Journal of Veterinary Research

the trapezoidal method AUMC Area under the first moment curve Cmax Maximum plasma concentration ERF Extended-release formulation MIC Minimum inhibitory concentration Vdss Apparent volume of distribution at steady state Footnotes a

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in American Journal of Veterinary Research