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synovial fluid at 24-hour intervals, which would exploit the postantibiotic effect of the aminoglycosides with daily, transient peak concentrations. ABBREVIATIONS MIC Minimum inhibitory concentration k e Elimination constant t

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in American Journal of Veterinary Research

traumatic fractures. Regional limb perfusion is a well-established method for delivering antimicrobials at concentrations greater than the minimum inhibitory concentration for many common bacterial pathogens into the synovium and osseous and soft tissue

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in American Journal of Veterinary Research

to treat septic arthritis in large animals 12 , 13 , 14 and achieves antimicrobial concentrations that exceed the minimum inhibitory concentrations for common bacterial pathogens for a prolonged duration. Local administration of antimicrobials is

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in American Journal of Veterinary Research