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clinical implications of these differences. ABBREVIATIONS MIC Minimum inhibitory concentration MIC 50 Minimum inhibitory concentration required to inhibit growth of 50% of bacterial isolates tested MIC 90 Minimum inhibitory concentration

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in American Journal of Veterinary Research

pharmacodynamic model LC-LHL Low peak concentration—long elimination half-life LOQ Limit of quantification MIC Minimum inhibitory concentration a. Becton-Dickinson, Franklin Lakes, NJ. b. Corning Costar 96-well plates, Sigma-Aldrich, St Louis, Mo

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in American Journal of Veterinary Research

infinity CFAE Ceftiofur free acid equivalent Cl Clearance C max Maximum plasma concentration CRI Continuous rate infusion C ss Plasma concentration at steady state λ z Elimination rate constant MIC Minimum inhibitory concentration t 1

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in American Journal of Veterinary Research

from each of these E coli isolates by use of a commercial kit a and tested for the presence of the AmpC β-lactamase gene ( blaCMY -2) by use of a PCR procedure described for previous studies. 18,19 Minimum inhibitory concentrations to a standard

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in American Journal of Veterinary Research

, Enterococcus spp, Pseudomonas spp, coagulase-negative Staphylococcus spp, and Streptococcus spp were > 4.0 μg/mL. Table 3— Minimum inhibitory concentrations of ceftiofur for bacteria isolated from various samples that had been obtained from 175

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in American Journal of Veterinary Research

–time curve CCFA Ceftiofur crystalline-free acid Cmax Maximum plasma concentration DCA Desfuroylceftiofur acetamide MIC Minimum inhibitory concentration TFA Trifluoracetic acid Tmax Time to maximum plasma concentration a. Excede, Pharmacia

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in American Journal of Veterinary Research

occur at trace concentrations. However, because of the variation in pharmacokinetics of various products, the results of our study cannot be generalized to all antimicrobials used in the treatment of nonlactating cows. Minimum inhibitory concentrations

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in American Journal of Veterinary Research

collection of blood samples. ABBREVIATIONS AUC Area under the plasma concentration–time curve C max Maximum drug concentration HPLC High-performance liquid chromatography k e Elimination rate constant MIC 90 Minimum inhibitory concentration

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in American Journal of Veterinary Research

plasma concentration Minimum inhibitory concentrations of ceftiofur for bacteria (293 isolates) that had been isolated from various rabbit clinical samples were determined. The clinical samples had been submitted to the William R. Pritchard Veterinary

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in American Journal of Veterinary Research

concentration MIC Minimum inhibitory concentration TEM Transmission electron microscopy a. American Type Culture Collection, Manassas, Va. b. Neogen Corp, Lansing, Mich. c. Sigma-Aldrich, St Louis, Mo. d. SPI Supplies / Structure Probe Inc

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in American Journal of Veterinary Research