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. Two dogs in the placebo group had signs of progressive osteoarthritis throughout the study. One dog developed a sudden lameness of the right hind limb during the second week of the study. The lameness resolved with NSAID and doxycycline administration

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in American Journal of Veterinary Research

incidents), heat or swelling (14), lameness or stiffness of the injected limb (14), and bruising or erythema at the injection site (13). Nonspecific reactions that occurred within 48 hours after vaccination included lethargy or signs of depression (14

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in American Journal of Veterinary Research

last G-CSF dose. Specific clinical signs that owners were verbally advised to monitor for included lameness (signs of bone pain), lethargy, inappetence or anorexia, nausea, vomiting, diarrhea, dyspnea or cough, skin bruising, or rash. Long-term adverse

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in American Journal of Veterinary Research

exposure, obesity, certain drugs, female sex, and certain breeds. 1–3 Clinical signs of TCC in the dogs are generally nonspecific and may include pollakiuria, stranguria, dysuria, tenesmus, and lameness. In addition to the challenge posed by nonspecific

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in American Journal of Veterinary Research