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increased risk for progression of osteoarthritis of the knee joint. 116 Cytokines Several cytokines are involved in cartilage metabolism and synthesized by synovial cells and cartilage chondrocytes. The interleukins are cytokines that have a primary

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in American Journal of Veterinary Research

caninized (ie, murine antibody genetically modified to contain sequences from canine IgG) anti-canine IL-31 mAb d has been developed to neutralize the effects of canine IL-31. 47 Interleukin-31 induces pruritus in various species, including rodents, dogs

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in Journal of the American Veterinary Medical Association

. 10.1016/0165-2427(93)90039-7 24. Goto M , Maruyama M , Kitadate K , et al. Detection of interleukin-1 beta in sera and colostrum of dairy cattle and in sera of neonates . J Vet Med Sci 1997 ; 59 : 437 – 441 . 10.1292/jvms.59.437 25

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in Journal of the American Veterinary Medical Association