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for future use in veterinary cancer gene therapies. Furthermore, in the field of veterinary oncology, the use of interleukin-2 as an antitumor treatment against canine tumors (albeit not mammary gland tumors) has been recently reported. 43–45 In

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in American Journal of Veterinary Research

such BRM is BCG, a bacterial cell wall derivative that incites an antitumor effect that is thought to be attributed, in part, to increases in interleukin-18 and subsequent increases in T-helper cell type-1 cytokines including interleukin-2 and

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in American Journal of Veterinary Research

stimulating platelet production or platelet release (or both) at the bone marrow level. 10 Thrombopoietic cytokines are being developed for this purpose. 1,10 The only such drug currently available is recombinant human interleukin-11. 11 This drug

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in American Journal of Veterinary Research

, interleukin-1α, interleukin-6, and interleukin-8. 19 Inhibition of angiogenesis by TM has been demonstrated in vitro and in vivo. 19,20 We hypothesized that the combination of doxorubicin and TM would induce more apoptosis and decrease proliferation of cells

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in American Journal of Veterinary Research

interleukin-1, interleukin-6, and tumor necrosis factor. 3 These mediators target the liver, which reacts to the stimulus by producing APPs. 4,5 Acute-phase proteins have been used as markers of infection, inflammation, and trauma in humans for several

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in American Journal of Veterinary Research

epulis IL Interleukin MM Malignant melanoma OPG Osteoprotegerin PNT Peripheral nerve sheath tumor POF Peripheral odontogenic fibroma RANK Receptor activator of nuclear factor-κB RANKL Receptor activator of nuclear factor-κB ligand SCC

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in American Journal of Veterinary Research

vascular endothelial growth factor receptors 1 and 2 and α v β 3 integrin, and to produce endothelial growth factors and cytokines such as vascular endothelial growth factor, basic fibroblast growth factor, and interleukin-8. 27 Enhanced TF expression in

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in American Journal of Veterinary Research

: 9991 – 9998 . 10.1158/0008-5472.CAN-05-1630 28 Messud-Petit F Gelfi J Delverdier M , et al. Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus . J Virol 1998 ; 72 : 7830

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in American Journal of Veterinary Research