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IL Interleukin NFκB Nuclear factor κB PPID Pituitary pars intermedia dysfunction SDHA Succinate dehydrogenase complex subunit A TNF-α Tumor necrosis factor-α TUBA1 Tubulin alpha 1 gene UBC Ubiquitin-C a. Horowitz ML, Neal L, Watson

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in American Journal of Veterinary Research

approximately 0.5 mm in diameter was created, destroying the monolayer of cells (n = 5). Cells either were treated with interleukin-6 (10 ng/mL) or remained untreated. Culture dishes were then transferred to a heated incubator chamber (5% CO 2 ) mounted on the

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in American Journal of Veterinary Research

,177 humans and then followed changes in LBM for 5 years. That study revealed that higher concentrations of inflammatory markers, including CRP, interleukin-6, and TNF-α were associated with a greater 5-year decrease in LBM, compared with humans with decreased

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in American Journal of Veterinary Research

receptor-mediated signaling, release of autocrine and paracrine factors (eg, interleukin 6) that stimulate surface receptors on cells and activate signaling cascades, 26 and muscle contraction per se. 27 Differential expression of proteins in fiber types

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in American Journal of Veterinary Research

type III increases in damaged tendons and ligaments. 9 In addition, MMP-13 expression is upregulated by interleukin-1β in damaged human tendons 10 and in naturally developing tendonitis in horses. 11 Matrix metalloproteinase-13 activity also

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in American Journal of Veterinary Research

, similar to the action of the known synovial inflammatory mediator, interleukin-1β. 40 In the study reported here, mepivacaine effectively eliminated lameness within 30 minutes after intra-articular administration, regardless of whether TA was

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in American Journal of Veterinary Research

methylprednisolone acetate and triamcinolone acetonide on interleukin-1-conditioned equine articular cartilage explants in vitro . Equine Vet J 2003 ; 35 : 444 – 450 . 10.2746/042516403775600479 30. Richardson DW , Dodge GR . Dose-dependent effects of

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in American Journal of Veterinary Research

. Expression of interleukin-1B in the digital laminae of horses in the prodromal stage of experimentally induced laminitis . Am J Vet Res 2001 ; 62 : 714 – 720 . 10.2460/ajvr.2001.62.714 5 Black SJ Lunn DP Yin C , et al . Leukocyte emigration

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in American Journal of Veterinary Research

on equine articular cartilage explants incubated with and without interleukin-1β . Am J Vet Res 2012 ; 73 : 1530 – 1539 . 10.2460/ajvr.73.10.1530 28. Duesterdieck-Zellmer KF Moneta L Ott JF , et al. Effects of low and high dose

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in American Journal of Veterinary Research

suspensory ligament. The horse, which was withdrawn from the study on day 10, had been receiving interleukin-1 receptor-antagonist protein until 1 week before beginning treatment with firocoxib. The other was a 6-year-old Thoroughbred gelding with grade 4

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in American Journal of Veterinary Research