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known to increase in response to LPS administration in horses. 30–33 Interleukin-1β, IL-6, and IL-8 are used as prognostic indicators in humans with sepsis, and increases in expressions of those cytokines predict organ failure and death. 34–36 In

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in American Journal of Veterinary Research

, New Orleans, May 2012. ABBREVIATIONS cACTH Canine ACTH IL Interleukin TNF Tumor necrosis factor Footnotes a. Coat-a-Count cortisol assay, Siemens Medical Solutions Diagnostics, Los Angeles, Calif. b. Coat-a-Count aldosterone

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in American Journal of Veterinary Research

at 0.5 h after infusion) SI (determined at 21 h after infusion) Sg (determined at 21 h after infusion) AUCi (determined at 21 h after infusion) Interleukin-1β –0.762 (0.028) — — — Interleukin-8 –0.810 (0.015) — –0

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in American Journal of Veterinary Research

, 9 hours, and 24 hours after LPS infusion fails to prevent the decrease in WBC count induced by endotoxemia. 42 However, dexamethasone pretreatment suppresses LPS-induced interleukin-1β and interleukin-6 responses in rats. 43 These mediators play a

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in American Journal of Veterinary Research

metabolism of the body but also endocrinologic and immunologic functions. 5,6 These metabolically active secretory products termed adipocytokines include leptin, tumor necrosis factor-A, adipsin, resistin, interleukin-6, plasminogen activator inhibitor-1

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in American Journal of Veterinary Research

serum interleukin-6 and TNF-α concentrations has also been reported. 23 Changes observed after endotoxin infusion in the horses in the present study, including changes in rectal temperature, WBC counts, and serum TNF-α concentration, were consistent

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in American Journal of Veterinary Research

22. Buerger C Richter B Woth K , et al. Interleukin-1β interferes with epidermal homeostasis through induction of insulin resistance: implications for psoriasis pathogenesis . J Invest Dermatol 2012 ; 132 : 2206 – 2214 . 10.1038/jid.2012

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in American Journal of Veterinary Research

parathyroid cells, and effects of interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha on equine parathyroid cell function . J Mol Endocrinol 2003 ; 31 : 609 – 620 . 10.1677/jme.0.0310609 17 Martell AE . Critically selected stability constants of

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in American Journal of Veterinary Research

of intramyocellular triglycerides, or increase in circulating NEFAs. Adipose tissue in obesity releases increased amounts of inflammatory cytokines, including tumor necrosis factor-α and interleukin-6, which may then directly interfere with insulin

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in American Journal of Veterinary Research

.M207198200 55 Sun L Hu FB Yu Z , et al. Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese . PLoS One 2011 ; 6 : e18104 . 10.1371/journal.pone.0018104 56 Yu D Yu Z Sun Q , et al. Effects of body

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in American Journal of Veterinary Research