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in many species. Cytokines are expressed in a variety of cells, especially when cells are under stress in situations such as invasion by foreign substances (eg, viruses and bacteria), allergic reactions, and trauma or injury. 1 Interleukin-6 acts as

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in American Journal of Veterinary Research

. J Vet Intern Med 1998 ; 12 : 26 – 35 . 10.1111/j.1939-1676.1998.tb00493.x 5. Barton MH Collatos C . Tumor necrosis factor and interleukin-6 activity and endotoxin concentration in peritoneal fluid and blood of horses with acute abdominal

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in American Journal of Veterinary Research

leads to production of interleukin-1, interleukin-6, and tumor necrosis factor with resulting hepatic production of amyloid precursors that have a β-pleated sheet configuration. 7 These precursors polymerize in the blood and then become trapped in the

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in American Journal of Veterinary Research

and LPS may provide additive or synergistic effects in horses that lead to the development of laminitis. Results of studies 6,16 indicate that expression of proinflammatory cytokines (including interleukins-1β and −6) and enzymes, molecules

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in American Journal of Veterinary Research

-1676.2006.tb00721.x 6. Fontaine GL Belknap JK Allen D , et al . Expression of interleukin-1B in the digital laminae of horses in the prodromal stage of experimentally induced laminitis . Am J Vet Res 2001 ; 62 : 714 – 720 . 10.2460/ajvr.2001

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in American Journal of Veterinary Research

. Fransson BA Lagerstedt A-S Bergström A , et al . C-reactive protein, tumor necrosis factor A and interleukin 6 in dogs with pyometra and SIRS . J Vet Emerg Crit Care [serial online] . Available at : www.blackwell-synergy.com/toc/vec/0

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in American Journal of Veterinary Research

-dependent Weibel-Palade bodies in VWD endothelial cells . Blood 2005 ; 105 : 145 – 152 . 10.1182/blood-2004-02-0464 28. Olsen EH McCain AS Merricks EP , et al. Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11

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in American Journal of Veterinary Research

.2830150405 13. Lee YJ Shin KC Kang SW , Type III procollagen N-terminal propeptide, soluble interleukin-2 receptor, and von Willebrand factor in systemic sclerosis . Clin Exp Rheumatol 2001 ; 19 : 69 – 74 . 14. Zhu GG

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in American Journal of Veterinary Research

A part from their role in hemostasis, platelets are involved in the initiation and propagation of inflammatory and immune processes via secretion of cytokines (eg, interleukin-1β and β-thromboglobulin) and interaction with other cells. 1

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in American Journal of Veterinary Research

. 5. Fontaine GL Belknap JK Allen D , et al. Expression of interleukin-1β in the digital laminae of horses in the prodromal stage of experimentally induced laminitis . Am J Vet Res 2001 ; 62 : 714 – 720 . 10.2460/ajvr.2001.62.714 6. Hurley

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in American Journal of Veterinary Research