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indicators can also be affected by factors other than renal insufficiency. Therefore, early biomarkers of AKI are needed to enable clinicians to detect patients with injury or at risk for ARF because of an overdose of an NSAID, which will allow for early

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in American Journal of Veterinary Research

injury and CKD are interconnected syndromes. 29 , 30 Comprehensive analysis of the renal transcriptome following RI may identify novel biomarkers, therapeutic targets, or both for cats with CKD. 31 The aim of the present study was to use RNAseq to

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in American Journal of Veterinary Research

other experiments that focused on leptospirosis-associated pulmonary hemorrhage syndrome. b Acute kidney injury was defined as acute onset of renal azotemia or evidence of acute tubular damage and compatible historical, clinical, clinicopathologic, and

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in American Journal of Veterinary Research

portion of the nephron is a metabolically active segment that can be easily damaged. As a result of renal tubular injury, renal tubular enzymes are subsequently released into the lumen of the nephron or into the urine. Various infections, nephrotoxins

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in American Journal of Veterinary Research

transplantation. The etiology of chronic posttransplantation hypertension in humans is multifold and includes genetic factors, concomitant disease, immunosuppressive treatment regimens, graft ischemic injury, the presence and severity of chronic allograft

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in American Journal of Veterinary Research

supraspinal centers via the spinal cord. Spinal cord injury in the thoracolumbar region leads to detrusor areflexia and increased urethral sphincter tone (ie, an upper motor neuron bladder) and eventually bladder dyssynergia. 5 The lack of afferent

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in American Journal of Veterinary Research

hypoxic event can trigger a profibrotic cascade that remains active for months after the insult. Acute kidney injury and CKD, although once considered separate disease entities, are now recognized as interconnected syndromes. 28,29 Results of the present

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in American Journal of Veterinary Research

method. 1–5 Although there are case reports of nephrotic syndrome with primary glomerular injury resulting in marked proteinuria, the most commonly reported histopathologic changes in the latter stages of feline CKD are tubulointerstitial inflammation

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in American Journal of Veterinary Research

time points prior to the start of the treatments prevented the inclusion of dogs with acute kidney injury, acute-on-chronic kidney disease, and prerenal azotemia. Exclusion criteria —Dogs were excluded from the study because of unstable azotemia

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in American Journal of Veterinary Research

have actually decreased the success of the catheters by preventing straining. Additional studies are needed to test this hypothesis. The angled shape of the curved angiographic catheters evaluated in the present study may lead to injury of the

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in American Journal of Veterinary Research