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, extracellular release of ROS can induce indiscriminate injury to host tissues. 20–22 Several in vitro studies 23–27 have revealed that activated neutrophils induce direct injury to bovine mammary gland epithelium and that scavengers of ROS protect against this

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in American Journal of Veterinary Research

Abstract

Objective

To determine the role of tissue factor (TF) in the coagulation events leading to intra-alveolar fibrin deposition and intravascular thrombosis associated with pneumonic pasteurellosis in cattle.

Animals

Healthy 2- to 4-week-old male Holstein calves.

Procedures

Blood and bronchoalveolar lavage samples were collected before and at 1, 2, 4, and 6 hours after inoculation of saline solution or Pasteurella haemolytica. Total leukocyte count, platelet count, plasma total protein concentration, prothrombin time, and partial thromboplastin time were measured in blood samples. Total nucleated cell count, total protein concentration, and procoagulant activity were measured in bronchoalveolar lavage samples. Additionally, platelet survival in blood, platelet accumulation in affected lung tissue, and gross and microscopic lung lesions were determined.

Results

Administration of TF monoclonal antibodies (MAB) TF1-1F7 prevented the decrease in platelet survival and the increase in bronchoalveolar lavage fluid TF-dependent procoagulant activity observed in calves not treated with MAB TF1-1F7 antibody, but did not attenuate the increase in lavage fluid neutrophil numbers and total protein concentration. MAB TF1-1F7 administration reduced the percentage of lung affected by pneumonic lesions from 51.81 % to 10.40% and attenuated intra-alveolar deposition of fibrin, neutrophils, and erythrocytes.

Conclusion

Intra-alveolar fibrin deposition and activation of coagulation in cattle with pneumonic pasteurellosis is, at least in part, mediated by TF.

Clinical Relevance

Treatments that neutralize TF activity may attenuate lung injury in cattle with pneumonic pasteurellosis (Am J Vet Res 1997;58:28–33)

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in American Journal of Veterinary Research

Numerous stresses such as weaning, infection, and inflammation can lead to intestinal mucosal injury in pigs, 1–3 which may result in diarrhea and poor growth of pigs. Therefore, modulation of injured intestines is extremely important in

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in American Journal of Veterinary Research

ischemia. 16 The mechanism by which lidocaine exerts its beneficial effects in animals with ischemic injury is not completely understood. Incubation of neutrophils from humans and rats with lidocaine reduces neutrophil respiratory burst, 17 adhesion, and

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in American Journal of Veterinary Research

High doses of MPSS have been used to treat dogs and humans with acute spinal cord injuries caused by trauma or intervertebral disk protrusion. 1–3 Spinal cord injuries, including intervertebral disk disease, are common clinical problems in dogs

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in American Journal of Veterinary Research

formation. 9,10 Methylprednisolone sodium succinate is a synthetic glucocorticoid that at high doses has free radical–scavenging properties. 11 In human medicine, the second National Acute Spinal Cord Injury Study 12 showed that high-dose treatment with

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in American Journal of Veterinary Research

In horses, endotoxemia, such as with strangulating and inflammatory lesions of the small intestines and large colon, is a leading cause of morbidity and death. 1,2 Ischemia-reperfusion injury and severe inflammation lead to intestinal mucosal

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in American Journal of Veterinary Research

. Noninfectious SIRS can be caused by conditions such as severe ischemia, hemorrhagic shock, or multiple trauma-associated tissue injuries and frequently results in dysfunction of multiple organs such as renal failure and acute lung injury. 2,3 Damage

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in American Journal of Veterinary Research

of febrile nonhemolytic transfusion reactions 13,28–30,39 lower mortality rates, 13,14 lower incidences of transfusion-related acute lung injury 40 and postoperative infections, 41 and lower rate of transmission of infectious disease agents such

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in American Journal of Veterinary Research

degree of COX-2 production occurs in traumatized muscle tissue. 14 In common garter snakes ( Thamnophis sirtalis ), the cellular response to cutaneous injury is characterized by a mixed heterophilic and histiocytic response, with heterophils

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in American Journal of Veterinary Research