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Carpal and metacarpophalangeal and metatarsophalangeal (ie, fetlock) joint injuries are common in Thoroughbred racehorses but can be difficult to detect clinically during the early stages of disease. As a result, joint disease often progresses to

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in American Journal of Veterinary Research

-1 concentrations in serum, plasma, and synovial fluid differed among untrained, race-trained, and osteochondral-injured racehorses. We hypothesized that training and osteochondral injury would increase serum, plasma, and synovial fluid SDF-1

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in American Journal of Veterinary Research

The metacarpophalangeal (fetlock) joint has the greatest number of traumatic and degenerative lesions of all joints in racehorses. 1 Common results of injury in this region are palmar and plantar osteochondral disease, which predominantly affect

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in American Journal of Veterinary Research

any species. Although the authors of the aforementioned studies did not address the use of HMGB-1 as a possible biomarker of joint health, the potential for this application should be considered. Early identification of joint injury and subsequent

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in American Journal of Veterinary Research

arthroscopic scores of joint injury severity. On the basis of observations in a previous study 36 in which serum and SF BAP activities were evaluated in horses with OCI, we hypothesized that exercise and OCI would increase SF CTX-II concentrations and decrease

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in American Journal of Veterinary Research

In adults, cartilage has limited potential for natural repair and thus injuries typically result in the progression of osteoarthritis. 1 The study of osteoarthritis is of particular interest in equine medicine because joint injury and joint

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in American Journal of Veterinary Research

injury. Type II collagen and aggrecan make up most of the extracellular matrix of articular cartilage. Disruption of the extracellular matrix is the hallmark of osteoarthritis, and as a result, biomarker development has focused on identifying byproducts

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in American Journal of Veterinary Research

Fractures of the PSB are one of the most common fatal musculoskeletal injuries incurred by Thoroughbred racehorses during racing and training. 1,2 Thirty to fifty percent of California Thoroughbred racehorse deaths have been attributed to PSB

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in American Journal of Veterinary Research

. Although the widespread consensus is that mechanical damage can initiate PTOA, little agreement exists as to whether the primary injury is to the articular cartilage, SCB, associated soft tissues, or combination of these structures. 6,13-16 Proponents of

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in American Journal of Veterinary Research

Thermal energy is used in > 100,000 procedures annually to treat partial-thickness injuries to cartilage. a Although temperature- and power-controlled devices are available for chondroplasty procedures, the clinical effect is the result of heat

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in American Journal of Veterinary Research