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of some human and experimental animal studies 12–14 have indicated that hyperglycemia is the main factor. Among dogs, DM is fairly common; type 1 DM is predominant and characterized by hypoinsulinemia and hyperglycemia. 15 Although dogs with DM

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in American Journal of Veterinary Research

mineralocorticoid effect 13,14 ; 2) plasma volume expansion, such as occurs in humans with hyperglycemia caused by uncontrolled diabetes mellitus, 15 as a result of glucose intolerance induced in cats by exogenous corticosteroids 16,17 ; 3) left ventricular

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in American Journal of Veterinary Research

expansion resulting from glucocorticoid-induced insulin resistance and hyperglycemia 8 ; direct glucocorticoid-induced structural cardiac remodeling, specifically left ventricular hypertrophy and diastolic dysfunction 9 ; and increased left ventricular

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in American Journal of Veterinary Research

the basis of findings of moderate to severe hyperglycemia and increased plasma volume following IM administration of methylprednisolone acetate to cats as monotherapy for dermatologic conditions, the authors concluded that an intravascular fluid shift

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in American Journal of Veterinary Research

secondary to mineralocorticoid effects leading to intravascular volume overload; glucocorticoid-induced hyperglycemia and subsequent plasma volume expansion by the shift of fluid from the extravascular to intravascular space; glucocorticoid

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in American Journal of Veterinary Research