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. 6729289 25. Rastrelli M , Tropea S , Rossi CR , Alaibac M . Melanoma: epidemiology, risk factors, pathogenesis, diagnosis and classification . In Vivo . 2014 ; 28 ( 6 ): 1005 – 1011 . 25398793 26. Gandini S , Sera F , Cattaruzza

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in Journal of the American Veterinary Medical Association

Abstract

Factors associated with foot abscess were evaluated in a cohort of 3,322 suckling pigs reared on a woven-wire floor (wire diameter, 0.5 cm; size of openings, 1 × 3.8 cm). In bivariate analysis, foot abscess was significantly (P < 0.05) associated with post-partum sow illness, number of pigs born alive, and parity, but not with birthweight (P = 0.31) or time spent on wire flooring (P = 0.89). One oxytetracycline treatment (100 mg, im) at birth or 1 treatment at birth and a second 5 to 7 days later reduced (P < 0.05) the risk of lesions by about half. Multivariate analyses indicated that pigs in large litters (> 10 pigs at birth) born to sows with postpartum illnesses had an increased risk (relative risk [rr], 3.77) of developing foot abscess, compared with pigs in small litters (≤ 10 pigs) born to unaffected sows. For sows without evidence of postpartum illness, pigs in large litters had a slightly increased risk (rr, 1.32) of developing foot abscess, compared with pigs in small litters. Pigs born to multiparous sows also had an increased risk (rr, 1.69) of developing foot abscess, compared with pigs born to primiparous sows. Similar risk estimates were obtained when logistic regression models included location farrowed (crate number) as fixed effect, and when litter was a random effect in a logistic-binomial regression.

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To evaluate the effects of twice-daily oral administration of a low-dose of trilostane treatment and assess the duration of effects after once-daily trilostane administration in dogs with naturally occurring hyperadrenocorticism (NOH).

Design—Prospective study.

Animals—28 dogs with NOH.

Procedures—22 dogs received 0.5 to 2.5 mg of trilostane/kg (0.23 to 1.14 mg/lb) orally every 12 hours initially. At intervals, dogs were reevaluated; owner assessment of treatment response was recorded. To assess drug effect duration, 16 of the 22 dogs and 6 additional dogs underwent 2 ACTH stimulation tests 3 to 4 hours and 8 to 9 hours after once-daily trilostane administration.

Results—After 1 to 2 weeks, mean trilostane dosage was 1.4 mg/kg (0.64 mg/lb) every 12 hours (n = 22 dogs; good response [resolution of signs], 8; poor response, 14). Four to 8 weeks later, mean dosage was 1.8 mg/kg (0.82 mg/lb) every 12 or 8 hours (n = 21 and 1 dogs, respectively; good response, 15; poor response, 5; 2 dogs were ill). Eight to 16 weeks after the second reevaluation, remaining dogs had good responses (mean dosages, 1.9 mg/kg [0.86 mg/lb], q 12 h [n = 13 dogs] and 1.3 mg/kg [0.59 mg/lb], q 8 h [3]). At 3 to 4 hours and 8 to 9 hours after once-daily dosing, mean post-ACTH stimulation serum cortisol concentrations were 2.60 and 8.09 μg/dL, respectively.

Conclusions and Clinical Relevance—In dogs with NOH, administration of trilostane at low doses every 12 hours was effective, although 2 dogs became ill during treatment. Drug effects diminished within 8 to 9 hours. Because of potential adverse effects, lower doses should be evaluated.

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in Journal of the American Veterinary Medical Association

Abstract

OBJECTIVE

To determine the impact of a free One Health clinic with human and veterinary services on the veterinary-client relationship for underserved pet owners. A secondary aim was to understand the experience of veterinary students and volunteers who participated in the clinic.

SAMPLE

78 pet owners, 55 students and 32 volunteers who attended the Delaware Humane Association One Health Clinic between December 2018 and November 2019.

PROCEDURES

Pet owners completed an anonymous questionnaire prior to and following their veterinary appointment regarding their trust in the veterinary profession, feelings of enablement and veterinarian-client concordance. Students and volunteers completed a questionnaire within 72 hours of clinic participation about their perceptions of the educational value of the clinic.

RESULTS

Following the One Health clinic, client trust in the veterinary profession increased significantly (t = –5.50, P < 0.001). Clients also reported high levels of enablement and veterinarian-client concordance. Students and volunteers agreed the clinic was a valuable educational experience (97.7%) and reported increased compassion, enhanced leadership, communication and teamwork skills, and an improved ability to identify social issues and think critically.

CLINICAL RELEVANCE

The results support the utilization of One Health clinics to improve access to veterinary care for underserved pet owners. Clients reported high levels of trust, enablement and concordance following the clinic which could have long-lasting effects on their willingness to seek veterinary care and comply with veterinarians’ recommendations. The positive experiences of students and volunteers also highlights the potential of low-cost veterinary clinics as unique educational experiences.

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in Journal of the American Veterinary Medical Association

Abstract

OBJECTIVE

To determine whether a single dose of trazodone administered to dogs before a veterinary visit reduced their behavioral and physiologic signs of stress and owners’ stress during veterinary visits.

SAMPLE

20 dogs and their owners.

PROCEDURES

In this randomized double-blinded placebo-controlled crossover clinical trial, dogs with a history of anxiety during veterinary visits were scheduled for 2 veterinary visits 1 week apart and randomly assigned to receive a single oral dose of either trazodone (9 to 12 mg/kg) or a placebo 90 minutes before transport to the veterinary clinic for alternate visits between September 21 and November 3, 2019. For each visit, we collected and assessed owner-completed surveys of dog stress score (DSS) and owner stress score; various investigator-reported scores, including from video-recorded behavior analyses; and patient-related physiologic data.

RESULTS

Dogs treated with trazodone versus placebo had lower mean DSSs, assessed by owners for physical examination and assessed by video analysis for time spent in the examination room; lower mean SD of normal-to-normal intervals, root mean square of successive heartbeat interval difference, and respiratory rate; and higher mean heart rate. No meaningful differences were observed in other behavioral or physiologic outcomes, including serum cortisol concentrations.

CLINICAL RELEVANCE

A single dose of trazodone before transport reduced signs of stress during veterinary visits for dogs in the present study and may be useful as an anti-anxiety medication for similarly affected dogs, potentially resulting in higher-quality clinical examinations and improved patient welfare.

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in Journal of the American Veterinary Medical Association

Abstract

OBJECTIVE

To determine the clinical and pathological findings of rabbits diagnosed with lymphoma.

ANIMALS

16 rabbits.

PROCEDURES

The medical and pathology records database of the Veterinary Medical Teaching Hospital at the University of California, Davis was searched for rabbits diagnosed with lymphoma from 1996 to 2019.

RESULTS

Mean age of the 16 rabbits was 8 years (range, 4.5 to 12 years). Immunophenotyping was performed in 14 cases. Diffuse, large, B-cell lymphoma was most common (n = 7) followed by epitheliotropic, T-cell lymphoma (2); type II enteropathy-associated, T-cell lymphoma (2); marginal-zone, B-cell lymphoma (1); peripheral, T-cell lymphoma not otherwise specified (cutaneous nonepitheliotropic lymphoma; 1); primary, mediastinal (thymic) large B-cell lymphoma (1), and unclassified (cytology only with no immunophenotyping; 2). Multiple chemotherapy protocols were used on the basis of each individual animal’s disease state. Initial clinical improvement was reported for most rabbits receiving chemotherapy (5/6), with diffuse B-cell lymphoma responding most favorably to treatment. The 11 rabbits included in the survival analysis had a median survival time of 60 days (range, 1 to 480 days), and those diagnosed with B- and T-cell lymphoma had a median survival time of 8 and 36 days (range, 1 to 150 and 1 to 90 days), respectively.

CLINICAL RELEVANCE

Rabbits develop a range of lymphoma subtypes and, similar to humans and dogs, diffuse large B-cell lymphoma appears to be the most common. Chemotherapy treatments followed multiple protocols, which were mostly well tolerated and had a highly variable response. Further research into chemotherapy protocols is needed to optimize treatment of lymphoma in rabbits.

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in Journal of the American Veterinary Medical Association

KF , Moore GE , Stoddard RA , Goldstein RE . 2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention . J Vet Intern Med . 2011 ; 25 ( 1 ): 1 – 13 . doi: 10.1111/j.1939

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in Journal of the American Veterinary Medical Association

of clinical MRSA strains from animal hosts . J Vet Sci . 2020 ; 21 ( 4 ): e54 . doi: 10.4142/jvs.2020.21.e54 32735092 25. Ortiz-Díez G , López R , Sánchez-Díaz AM , Epidemiology of the colonization and acquisition of methicillin

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in Journal of the American Veterinary Medical Association