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parasympathetic tone and inhibit motility and secretion of the gastrointestinal tract. 8 Dogs confined in cages in a hospital environment have significantly different gastric emptying times, compared with dogs in their normal home environment. 9 – 11 These

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in American Journal of Veterinary Research

Abstract

Objective

To determine alteration in adrenocortical function in horses with recurrent airway obstruction (heaves) after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively.

Animals

6 horses with inducible and reversible heaves.

Procedure

Episodes of heaves were induced by exposure to moldy hay and straw for 7 days (natural challenge). Horses then underwent treatment (aerosolized beclomethasone, parenterally administered dexamethasone, and aerosolized propellant) for 7 days. Horses remained in the mold-contaminated environment for 7 days after discontinuation of drugs. Adrenocortical function was determined by serial evaluation of Cortisol concentration in serum obtained on days 0, 7, 9, 12, 14, 16, 19, and 21. Adrenocorticotropic hormone stimulation testing was performed in 4 horses/treatment group on days 0, 7, 14, and 21.

Results

Endogenous Cortisol production was suppressed in beclomethasone- and dexamethasone-treated horses within 2 days of treatment but recovered to values similar to those in propellant-treated horses approximately 2 and 4 days after discontinuation of drugs. Serum Cortisol concentration in propellant-treated horses gradually decreased during the study and was significantly lower than baseline on days 14, 16, 19, and 21. Mean increase in serum Cortisol concentration in response to ACTH stimulation testing after beclomethasone and dexamethasone administration did not differ significantly from the response observed in propellant-treated horses.

Conclusions

Aerosol and parenteral administration of beclomethasone and dexamethasone, respectively, suppressed adrenocortical function; however, endogenous cortisol production resumed approximately 2 and 4 days after discontinuation of drugs. Responsiveness to ACTH stimulation testing was not affected by the 7-day treatment period. (Am J Vet Res 1998;59:1044–1047)

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in American Journal of Veterinary Research

.50 mg/kg) in a crossover study. Status Score Definition Calm 0 Dog is tranquil and interacts normally with people and its environment Slight agitation 1 Dog is apprehensive and requires reassurance through

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in American Journal of Veterinary Research

Local and systemic inflammation is recognized as contributing to the development of a prothrombotic environment in the microvasculature. 1 For several diseases of horses, including acute laminitis and limb cellulitis, the formation of thrombi

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in American Journal of Veterinary Research

preconditioned to the hospital environment. Each dog was individually housed in an indoor run (1.4 × 0.9 m) and had ad libitum access to water for the duration of the sample collection period. Each dog was fed 1 hour prior to trazodone administration and again

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in American Journal of Veterinary Research

of gastric ulcers. 32 The stress of housing in the laboratory environment and repeated restraint for anesthesia, monitoring, and treatments could cause psychogenic stress. However, there is no evidence within the veterinary literature that the

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in American Journal of Veterinary Research

the sea stars to their normal aquarium environment following immersion in the enrofloxacin solution. Pharmacokinetic analyses The initial pharmacokinetic parameters for enrofloxacin determined by the naïve averaged pooled sample method were

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in American Journal of Veterinary Research

the head position, apparent lack of awareness of the environment, and an increase in blinking, all of which were noted for approximately 4 to 5 minutes. There were no changes in heart rate following IV administration. Changes in behavior and heart rate

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in American Journal of Veterinary Research

some awareness of environment, responds to stimuli through body movement, and may be laterally or sternally recumbent), or unresponsive (in a state of coma or semicoma in which little or no response can be elicited; remains in lateral recumbency). 22

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in American Journal of Veterinary Research

their body weight in water once given access. This finding suggested that inland bearded dragons were less prone to environmentally induced dehydration than other reptile species not adapted to arid environments. Overall, the results of the study

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in American Journal of Veterinary Research