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associated with in vitro and preclinical rodent studies. 10 , 11 Dogs often occupy the same environment as people do and are often inadvertently exposed to the same carcinogens. Interestingly, dogs can develop spontaneous tumors with histopathologic

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in American Journal of Veterinary Research

mimics an environment with rapid and complete fluid exchange, and 1 that mimics an environment where no fluid exchange occurs. We hypothesized that eluent samples obtained by the 2 distinct methods would result in differences in eluent platinum

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in American Journal of Veterinary Research

and given ZnPcS 4 (concentration, 1 mg/mL) as a slow IV bolus. After injection, they were kept in a low-light environment and monitored for adverse reactions attributable to the photosensitizer. Twenty-four hours after injection, dogs were

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in American Journal of Veterinary Research

similar age and body weight, had a similar environment and diet, and did not receive prior chemotherapy) to properly establish baseline pharmacokinetic data. It is possible that exposure to drugs may be altered in cats with gastrointestinal lymphoma or

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in American Journal of Veterinary Research

antimicrobials (penicillin [100 U/mL] and streptomycin [0.1 mg/mL]). All cell lines were maintained in a humidified environment of 95% room air and 5% carbon dioxide at 37°C. The doubling times of these cell lines for these culture conditions were approximately

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in American Journal of Veterinary Research

or minor variations in the clinical environment. Therefore, in lieu of parametric tests, distribution-free nonparametric tests were chosen for all statistical comparisons. 19 For phase 1, Fisher exact tests were used to rule out differences in

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in American Journal of Veterinary Research

Eagle medium high glucose a with L-glutamine and sodium pyruvate and supplemented with 10% heat-inactivated fetal bovine serum b and 100 U of penicillin-streptomycin/mL. c Cells were grown in T-75 flasks at 37°C in a humidified environment with 5

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in American Journal of Veterinary Research

kidneys 11,12,21 ). Thermal ablation induces irreversible cellular injury by creating a focal high-temperature environment (> 54°C for at least 3 minutes or 60°C reached instantaneously). 11,22,23 Several thermal ablation methods exist, including

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in American Journal of Veterinary Research

contouring). All plates were stored in a dry and dark environment until electrochemical investigations were performed. Electrochemical corrosion and ion release measurements—Plate selection for electrochemical corrosion measurements and detection of local

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in American Journal of Veterinary Research

naturally occurring tumors have not yet been published to the authors' knowledge. A recent report 18 illustrates the advantages of incorporating companion animal studies into anti-cancer drug development. For example, dogs share our environment and are

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in American Journal of Veterinary Research