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SUMMARY

Interleukin-1 (il-1) is a protein secreted by stimulated cells of the monocyte-macrophage line, which has a number of important biologic activities. Interleukin-1 has been implicated in the induction and augmentation of the pathologic processes involved in arthritis and articular cartilage destruction. Horses develop osteoarthritis with a frequency and degree of severity similar to human beings. To further document the similarity of the osteoarthritic process in people and horses, the synovial fluid from 5 horses with clinical osteoarthritis was tested for il-1 bioactivity. Interleukin-1 activity was found in all tested synovial fluids. Upon column chromatography, the synovial fluid-derived factor had a molecular weight consistent with that of il-1 in other mammalian species. Ion exchange chromatography of osteoarthritic synovial fluid revealed the principal peaks of bioactivity to be in the fractions with isoelectric points of 7.2, 5.4, and 4.7, which are characteristic of il-1. A considerable degree of homology between human and equine il-1 was demonstrated by the cross hybridization of a human il-1β cDNA probe with rna derived from il-1-producing equine adherent monocytes. These results indicate that equine il-1 is in all of the osteoarthritic equine joints tested and that equine il-1 has many of the characteristics of il-1 isolated from other species.

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in American Journal of Veterinary Research

confirmed on the basis of the presence of joint effusion, lameness, high synovial fluid WBC count, and high synovial fluid TP and SAA concentrations. For all treatments, sterile, preservative-free morphine in individual-use vials b with an initial

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in American Journal of Veterinary Research

H Burgess LJ Carstens ME , et al. Characterization of the immunological features of tuberculosis pericardial effusions in HIV positive and HIV negative patients in contrast with non-tuburculosis effusions . Tuberculosis 2006 ; 86 : 125

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in American Journal of Veterinary Research