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Introduction Diabetes mellitus is one of the most common endocrinopathies affecting dogs. It is estimated that 1 in 100 dogs to 1 in 500 dogs will develop DM. 1 Diabetes mellitus–associated ocular changes such as cataracts, decreased corneal

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in American Journal of Veterinary Research

Diabetes mellitus is a common endocrinopathy in dogs, with reported prevalence ranging from 1 in 100 to 1 in 500 dogs affected. 1 The cause of DM in dogs is multifactorial, and studies 2–5 suggest that genetics, environmental factors, and immune

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in American Journal of Veterinary Research

affect corneal innervation, which can result in decreased corneal sensitivity and the development of neurotrophic keratopathy. In human patients, neurotrophic keratopathy has been associated most frequently with long-standing diabetes mellitus, herpes

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in American Journal of Veterinary Research

In dogs, diabetes mellitus is characterized by the rapid appearance of bilateral sugar cataracts. Over the past 30 years, the incidence of canine diabetes mellitus has increased 3-fold. 1,2 Currently, nearly 1 in 3 dogs with cataracts is also

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in American Journal of Veterinary Research

nerve morphology in eyes of dogs . Am J Vet Res 2002 ; 63 : 906 – 915 . 10.2460/ajvr.2002.63.906 13. Good KL Maggs DJ Hollingsworth SR , Corneal sensitivity in dogs with diabetes mellitus . Am J Vet Res 2003 ; 64 : 7 – 11 . 10

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in American Journal of Veterinary Research

nerve anatomy in normal dogs . Prog Vet Comp Ophthalmol 1991 ; 1 : 245 – 254 . 8. Good KL Maggs DJ Hollingsworth SR , et al . Corneal sensitivity in dogs with diabetes mellitus . Am J Vet Res 2003 ; 64 : 7 – 11 . 10.2460/ajvr.2003

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in American Journal of Veterinary Research

radicals, hydroxyl anions, and hydrogen peroxide. Production of ROS can result in lipid peroxidation, protein oxidation, and DNA damage. 2 Oxidative stress has been linked to chronic diseases in humans, including diabetes mellitus, Alzheimer's disease

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in American Journal of Veterinary Research

analysis , in Proceedings . 30th Annu SAS Users Group Int Conf 2005 ; 30 : 1 – 8 . 23. Wilkie DA Gemensky-Metzler AJ Colitz CMH , et al. Canine cataracts, diabetes mellitus and spontaneous lens capsule rupture: a retrospective study of 18

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in American Journal of Veterinary Research

-Vaz JG Leite E Ramos MC , eds. Manual of ocular fluorophotometry . Coimbra, Portugal : Coimbra , 1993 ; 51 – 67 . 23. Larsson L Pach JM Brubaker RF . Aqueous humor dynamics in patients with diabetes mellitus . Am J Ophthalmol

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in American Journal of Veterinary Research

cataracts include nutritional deficiencies, certain toxins, trauma, inflammation, endocrine disorders (eg, diabetes mellitus), and senility. 1 Cataracts are a well-documented cause for vision loss in both domestic and nondomestic species, and tigers are not

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in American Journal of Veterinary Research