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SUMMARY

Characteristic alterations in the serum and urine biochemical profiles of Doberman Pinschers with congestive heart failure (chf) resulting from idiopathic dilated cardiomyopathy were determined. We compared these alterations with those observed in 2 other models of chf: rate overload induced by rapid ventricular pacing in dogs, and biventricular hypertrophy and dilatation induced in turkey poults by furazolidone toxicosis. Serum and urine biochemical changes in both models of chf in dogs were mild to moderate in degree, and were moderately consistent. They could be attributed to secondary neurohumoral, hepatic, and renal effects of heart failure. The most marked and consistent changes observed were mildly decreased anion gap that developed, in part, because of decreased serum sodium concentration, moderately increased catecholamine concentrations, moderate lactaciduria, hyposthenuria, and mildly increased urea concentrations and liver enzyme activities. In birds with furazolidone cardiomyopathy, we observed mild increases in serum urate concentration, liver and muscle enzyme activities, but moderately increased sodium concentration with decreased chloride concentration. In the pacing and furazolidone models, in which chf was rapidly induced, moderate to marked hypoproteinemia was attributable to decreases in albumin and globulin concentrations. Using the avian model we found that the hypoproteinemia could be largely attributed to blood volume expansion, and to a lesser extent, inanition. Development of hypoalbuminemia during rapid ventricular pacing and furazolidone treatment may contribute to the effects of rate overload or drug toxicity in the pathogenesis of chf, because hypoalbuminemia may contribute to altered hemodynamics and neuroendocrine system activation. Our data indicate that clinical biochemical analysis of serum and urine may be useful for assessing progression of chf.

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in American Journal of Veterinary Research

Abstract

Objective

To test the hypothesis that the derangement of myocardial energy homeostasis characteristic of idiopathic dilated cardiomyopathy (IDCM) of Doberman Pinschers was attributable to deficiency of creatine kinase (CK) isoenzyme MB relative to CK isoenzyme MM and troponin-T (Tn-T).

Animals

9 Doberman Pinschers with advanced congestive heart failure attributable to IDCM and 9 mixed-breed dogs without cardiac disease (controls).

Procedure

Myocardial myofibrillar CK-MM, mitochondrial CK, and cytosolic CK-MB activities were determined in comparison with the concentration of cardiac-specific, myofibrillar protein Tn-T. Myocardial biopsy specimens were obtained after euthanasia and were ultrafrozen. Isoenzymes of CK were separated eloctrophoretically, and their activity was determined, using a coupled-enzyme, kinetic, fluorescent assay and densitometry. Troponin-T content was determined by immunoassay.

Results

Myofibrillar CK-MM and mitochondrial CK activities and Tn-T content were 25% lower in the dogs with IDCM than in controls, whereas cytosolic CK-MB activity was 50% lower.

Conclusion

Deficiency of CK-MB activity is a component of and may have a central role in the energy deficiency characteristic of failing myocardium in IDCM of Doberman Pinschers. A side-product of this study was the observation that, in dogs, CK-MB activity and Tn-T content of myocardium are sufficiently high to be candidate serum markers for active cardiac injury. (Am J Vet Res 1997;58:11–16)

Free access
in American Journal of Veterinary Research

Congestive heart failure is a clinical syndrome caused by chronic heart disease and is characterized by sodium and water retention that results in edema. Loop diuretics are recommended as a first-line treatment in the management of CHF and are

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in American Journal of Veterinary Research

coronary artery disease, 26 congestive heart failure, 27 sepsis, 13 and MODS. 10,11,28 Similarly, studies 16,17 of humans have used flow cytometry to confirm platelet microparticle release in diseases or conditions such as neoplasia, acute coronary

Full access
in American Journal of Veterinary Research

), seizures (2), congestive heart failure (1), congestive heart failure and chronic renal failure (1), diabetic ketoacidosis and pancreatitis (1), immunemediated polychondritis (1), protein-losing enteropathy (1), pulmonary contusion (1), weakness or collapse

Full access
in American Journal of Veterinary Research

clinically normal dogs 4,5 and dogs with congestive heart failure. 6 In those studies, most of the lactate concentration measurements were performed on venous blood samples, primarily those obtained from the dogs' jugular veins. However, it has been

Full access
in American Journal of Veterinary Research

congestive heart failure . J Vet Intern Med 2007 ; 21 : 451 – 457 . 10.1111/j.1939-1676.2007.tb02989.x 11. Donahue SM Otto CM . Thromboelastography: a tool for measuring hypercoagulability, hypocoagulability, and fibrinolysis . J Vet Emerg Crit

Full access
in American Journal of Veterinary Research