Search Results

You are looking at 1 - 10 of 11 items for :

  • Refine by Access: All Content x
Clear All

controlling the progression of epilepsy. ABBREVIATIONS EEG Electroencephalography GFAP Glial fibrillary acidic protein Iba-1 Ionized calcium–adapter molecule 1 IL Interleukin TNF Tumor necrosis factor VEGF Vascular endothelial growth

Full access
in American Journal of Veterinary Research

BMSCs after neuronal induction has been examined with calcium imaging and patch clamp recording; the results suggest that human, mouse, and rat BMSCs have the potential to differentiate into functional neurons. 16,18 A recent clinical trial 3

Full access
in American Journal of Veterinary Research

concentration in the CSF of subjects with experimentally induced and spontaneous IE, but the findings regarding GABA concentrations in the CSF are less consistent. Glutamate causes activation of N -methyl- d -aspartic acid receptors, which opens calcium

Full access
in American Journal of Veterinary Research

acids initiates a complex process of cellular injury, which if uninterrupted, will result in calcium influx and cell death. 31,50,51 Excitotoxicosis is triggered by the excessive release of glutamate from presynaptic nerve terminals and astrocytes into

Full access
in American Journal of Veterinary Research

, and the effect of tolerance development . Can J Physiol Pharmacol 1991 ; 69 : 1257 – 1261 . 10.1139/y91-184 33. Murad F. Drugs used for the treatment of angina: organic nitrates, calcium channel blockers, and beta-adrenergic antagonist . In

Full access
in American Journal of Veterinary Research

calcium release and a decrease in neuronal excitation. 1–3 Levetiracetam has been approved by the US FDA for use in the treatment of a variety of seizure disorders in humans. 2,4–6 Levetiracetam is not currently approved by the US FDA for use in dogs and

Full access
in American Journal of Veterinary Research

and antagonism of G protein-mediated calcium influx . Biochem Pharmacol . 2004 ; 67 ( 12 ): 2251 – 2262 . 10.1016/j.bcp.2004.02.020 45. Seo SM , McIntire LV , Smith CW . Effects of IL-8, Gro-α, and LTB4 on the adhesive kinetics of LFA-1

Full access
in American Journal of Veterinary Research

understood, it is novel, compared with that for the classical AEDs. Levetiracetam interacts with neuronal synaptic vesicular (SV2A) receptors, thereby modulating calcium-dependent exocytosis of neurotransmitters. 1 It also suppresses the inhibitory effect of

Full access
in American Journal of Veterinary Research

Glutamate initiates a pathogenic cascade that results in cellular overload of calcium and increased production of ROS. 5 In addition, an inflammatory response is initiated, with recruitment of neutrophils and macrophages and upregulation of cellular

Full access
in American Journal of Veterinary Research

dopaminergic and serotonergic systems, binding to γ-aminobutyric acid chloride channels, inhibition of glutamate release, and blockage of t-type calcium and voltage-gated sodium channels. 2–4 Zonisamide is most commonly used as an adjunctive maintenance

Full access
in American Journal of Veterinary Research