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limit of quantitation). Total calcium, creatinine, BUN, and bone biomarker evaluations —Total calcium in plasma of the horses was measured before zoledronic acid infusion and 8 hours, 24 hours, 4 days, 7 days, 28 days, and 9 weeks after administration

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in American Journal of Veterinary Research

fillers and cements. 20–31 In the past decade, the clinical application of bone fillers and cements as bone substitutes in trauma and orthopedic surgery became established, and their use has increased exponentially. 32–39 Particularly, calcium phosphate

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in American Journal of Veterinary Research

construct. 12,20,25,35,38,39 Calcium phosphate cement was the first biodegradable bone cement to be made commercially available. It can tolerate high compressive strength, fill in gaps between implant and bone, 40–42 act as an osteoconductive medium, 43

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in American Journal of Veterinary Research

, including calcitriol, vitamin D, calcium, and bisphosphonates, have been used to prevent or reduce osteopenia in humans. Among those medications, bisphosphonates are well-established agents for treating a variety of bone diseases and are most commonly

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in American Journal of Veterinary Research

, the mean difference in CK activity between days 6 and 1 did not differ significantly among the 3 groups. The mean plasma calcium concentration increased from day 1 to day 6 for the control and IVRLP groups and decreased for the IORLP group. The

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in American Journal of Veterinary Research

radius curvus syndrome caused by ulnar growth plate trauma, 16 osteochondrosis, 17 or excessive intake of calcium 14 or vitamin D. 18 Therefore, we concluded that this developmental abnormality originated in the middiaphysis of the radius, with

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in American Journal of Veterinary Research

in stalls. 3 Additionally, calcium concentration and pyridinoline cross-links increased significantly less in subchondral bone in foals confined to stalls than in those raised on pasture or trained. 5 Correspondingly, stall confinement in Arabian

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in American Journal of Veterinary Research

administration of calcium PPS (10 mg/kg, q 7 d) maintained the normal articular cartilage ratio of aggrecan to dermatan sulfate (interpreted by the authors as chondrocyte phenotype). 14 Sodium PPS also stimulates hyaluronan synthesis by cultured synoviocytes

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in American Journal of Veterinary Research

collection (within 5 hours) at the Animal Health Laboratory, University of Guelph. Serum biochemical analyses —Analyses were performed by use of an automated biochemical analyzer. d Data collected from each serum sample included calcium, phosphorus

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in American Journal of Veterinary Research

systemic administration, bisphosphonates have a high affinity for and bind to hydroxyapatite in bone. Bisphosphonates prevent bone resorption by chelation of the calcium ions of hydroxyapatite and the induction of osteoclast apoptosis via inhibition of

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in American Journal of Veterinary Research