Search Results

You are looking at 1 - 7 of 7 items for :

  • "bupivacaine" x
  • Refine by Access: All Content x
Clear All

Abstract

Objective

To evaluate effects of interpleural or IM administration of morphine and interpleural administration of bupivacaine on pulmonary function in dogs that have undergone median sternotomy.

Design

Experimental trial.

Animals

18 healthy dogs.

Procedure

Dogs underwent median sternotomy and were randomly assigned to groups of 6 dogs each. Group-A dogs were given morphine (1.0 mg/kg of body weight) IM; group-B dogs were given 0.5% bupivacaine (1.5 mg/kg) interpleurally; and group-C dogs were given morphine (1.0 mg/kg) interpleurally. Heart rate; systolic, diastolic, and mean arterial pressures; rectal temperature; pain score; and arterial blood gas partial pressures were measured and pulmonary function testing was performed immediately after extubation (time 0) and up to 48 hours later. Serum cortisol and morphine concentrations were measured at time 0 and up to 12 hours after surgery.

Results

There was a significant decrease in pH, Pao2, mean oxygen saturation of hemoglobin, and dynamic compliance; and a significant increase in Paco2. alveolar-arterial difference in partial pressure of oxygen, pulmonary resistance, and work of breathing for dogs in all groups after surgery. Serum cortisol concentrations were significantly increased, compared with preoperative values, in all dogs. Serum cortisol concentrations were significantly higher in group-B dogs between 3 and 5 hours after surgery, compared with group-A dogs.

Conclusions

Median sternotomy was associated with significant alterations in pulmonary function. Effects of interpleural administration of bupivacaine and morphine were similar to effects of IM administration of morphine.(Am J Vet Res 1996;57:375-380)

Free access
in American Journal of Veterinary Research

SUMMARY

Eighteen dogs undergoing lateral thoracotomy at the left fifth intercostal space were randomly assigned to 1 of 3 postoperative analgesic treatment groups of 6 dogs each as follows: group A, morphine, 1.0 mg/kg of body weight, im; group B, 0.5% bupivacaine, 1.5 mg/kg given interpleurally; and group C, morphine, 1.0 mg/kg given interpleurally. Heart rate, respiratory rate, arterial blood pressure, arterial blood gas tensions, alveolar-arterial oxygen differences, rectal temperature, pain score, and pulmonary mechanics were recorded hourly for the first 8 hours after surgery, and at postoperative hours 12, 24, and 48. These values were compared with preoperative (control) values for each dog. Serum morphine and cortisol concentrations were measured at 10, 20, and 30 minutes, hours 1 to 8, and 12 hours after treatment administration.

All dogs had significant decreases in pHa, PaO2 , and oxygen saturation of hemoglobin, and significant increases in PaCO2 and alveolar-arterial oxygen differences in the postoperative period, but these changes were less severe in group-B dogs. Decreases of 50% in lung compliance, and increases of 100 to 200% in work of breathing and of 185 to 383% in pulmonary resistance were observed in all dogs after surgery. Increases in work of breathing were lower, and returned to preoperative values earlier in group-B dogs. The inspiratory time-to-total respiratory time ratio was significantly higher in group-B dogs during post-operative hours 5 to 8, suggesting improved analgesia. Blood pressure was significantly lower in group-A dogs for the first postoperative hour. Significant decreases in rectal temperature were observed in all dogs after surgery, and hypothermia was prolonged in dogs of groups A and C. Significant differences in pain score were not observed between treatment groups. Cortisol concentration was high in all dogs after anesthesia and surgery, and was significantly increased in group-B dogs at hours 4 and 8. Significant differences in serum morphine concentration between groups A and C were only observed 10 minutes after treatment administration. In general, significant differences in physiologic variables between groups A and C were not observed.

Results of the study indicate that anesthesia and thoracotomy are associated with significant alterations in pulmonary function and lung mechanics. Interpleurally administered bupivacaine appears to be associated with fewer blood gas alterations and earlier return to normal of certain pulmonary function values. Interpleural administration of morphine does not appear to provide any advantages, in terms of analgesia or pulmonary function, compared with its im administration.

Free access
in American Journal of Veterinary Research

were apposed with a simple continuous pattern with 2-0 polydioxanone. Bupivacaine (5.3 mg/kg) was injected peri-incisionally at the time of surgical closure. The skin was then apposed with a continuous intradermal pattern of 3-0 polyglactin 910, and

Open access
in American Journal of Veterinary Research

. 10.2460/ajvr.2005.66.907 17. Shafford HL Hellyer PW Turner AS . Intra-articular lidocaine plus bupivacaine in sheep undergoing stifle arthrotomy . Vet Anaesth Analg 2004 ; 31 : 20 – 26 . 10.1111/j.1467-2995.2004.00126.x 18. Pettifer

Full access
in American Journal of Veterinary Research

block (0.5% bupivacaine; 1 mg/kg divided evenly between the 12th and 13th ribs) was administered, and the diaphragm then was closed by use of 2-0 polydioxanone in a continuous pattern with intermittent circumcostal passes. The thoracic cavity was closed

Full access
in American Journal of Veterinary Research

) for analgesia. After induction of anesthesia and 30 minutes prior to skin incision, epidural anesthesia was administered with bupivacaine (0.5 mg/kg) via L7-S1. Each dog was positioned in ventral recumbency and restrained so that the hind limbs were

Full access
in American Journal of Veterinary Research

bloodless castration methods in calves . Vet J 2007 ; 173 : 333 – 342 . 10.1016/j.tvjl.2005.08.031 14. Carpenter RE Wilson DV Evans AT . Evaluation of intraperitoneal and incisional lidocaine or bupivacaine for analgesia following

Full access
in American Journal of Veterinary Research