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SUMMARY

Ochratoxin A (oa) was incorporated in the diets of growing gilts (mean body weight, 20.1 kg) at a concentration of 2.5 mg of oa/kg of feed and was fed continuously for 35 days. Humoral and cell-mediated immunologic measurements were evaluated to determine the effects of oa on immune function in swine. Cutaneous basophil hypersensitivity to phytohemagglutinin (pha), delayed hypersensitivity to tuberculin, pha-induced lymphocyte blastogenesis, interleukin-2 production, total and isotype immunoglobulin concentrations, antibody response to chicken rbc, and macrophage activation were used to evaluate immune function. Gilts treated with oa had reduced cutaneous basophil hypersensitivity response to pha, reduced delayed hypersensitivity to tuberculin, decreased stimulation index for lymphoblastogenesis, decreased interleukin-2 production when lymphocytes were stimulated with concanavalin A, and decreased number and phagocytic activity of macrophages. Differences were not observed for total and isotype immunoglobulin concentrations, or humoral hemagglutination (chicken rbc) titer. These data indicate that oa may suppress cell-mediated immune response in growing swine.

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in American Journal of Veterinary Research

azathioprine to 6-mercaptopurine. 6-Mercaptopurine is metabolized by 3 competitive pathways; it can be inactivated by XOD to form thiouric acid, metabolized by TPMT to form 6-MMP, or activated by HPRT to form 6-TIMP, which is then metabolized to 6-TGN, the

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in American Journal of Veterinary Research

potential to markedly affect reticuloruminal function. 11,12 The effects of ergotamine and its activation of various receptors have been widely studied. 9 In contrast, ergovaline isolate has only recently become available, and studies of its effects are

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in American Journal of Veterinary Research

of ipecac-induced emesis, orogastric lavage, and activated charcoal for acute drug overdose . Ann Emerg Med 1987 ; 16 : 838 – 841 . 10.1016/S0196-0644(87)80518-8 4. Pond SM Lewis-Driver DJ Williams GM , et al . Gastric emptying in

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in American Journal of Veterinary Research

1994 ; 36 : 511 – 514 . 28. Aeschlimann JA Reinert M . Pharmacological action of some analogues of physostigmine . J Pharmacol Exp Ther 1931 ; 43 : 413 – 444 . 29. Kolta MG Soliman KF . Effect of peripheral cholinergic activation on

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in American Journal of Veterinary Research

the neurotransmitter acetylcholine from binding to and activating the receptor. As a result of this receptor blockade, clinical signs in cattle with larkspur toxicosis include muscle weakness, tachycardia, loss of voluntary muscular coordination

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in American Journal of Veterinary Research

: 96 – 102 . 3. Pistol GC Gras MA Marin DE , et al. Natural feed contaminant zearalenone decreases the expressions of important pro- and anti-inflammatory mediators and mitogen activated protein kinase/NF-Kb signaling molecules in pigs . Br

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in American Journal of Veterinary Research