Search Results

You are looking at 1 - 10 of 24 items for :

  • "activation" x
  • Ophthalmology x
  • Refine by Access: All Content x
Clear All

anti-inflammatory properties. 4,15,16 In human retinal pigmented epithelial and HeLa cells, RES can inhibit the activation of MAPK signaling molecules, such as ERK 1/2, JNK, and p38, which control cell migration, proliferation, and differentiation. 6

Full access
in American Journal of Veterinary Research

; however, they are of important consideration because they can be activated by various factors and can be involved in physiopathologic processes. 11 Once activated, MMPs lose approximately 10 kd in molecular weight and require Ca 2+ for their stability

Full access
in American Journal of Veterinary Research

humor of healthy individuals. 15 , 16 , 17 , 18 Tissue plasminogen activator, plasminogen activator inhibitor-1, and other protease activators and inhibitors have also been found in clinically normal eyes and are suspected to act on MMPs and other

Full access
in American Journal of Veterinary Research

. Migration and activation of CECs and fibroblasts play an integral role in the closure of corneal wounds. 45,46 For both CECs and corneal fibroblasts, wound healing experiments in the present study revealed no significant differences in the rates of cellular

Full access
in American Journal of Veterinary Research

Allergic responses involve a cascade of events coordinated by mast cells. These activated mast cells release mediators, including histamine, that cause clinical signs of allergic inflammation via activation of inflammatory cells. Histamine

Full access
in American Journal of Veterinary Research

infectious agents on corneal cytologic evaluation and microbial cultures and by a positive response to immunosuppressive medications; however, the inciting antigens, mechanisms of activation, and specific nature of the resultant inflammatory response are

Full access
in American Journal of Veterinary Research

in the retinas of humans with primary open-angle glaucoma, but only HSP 60 is upregulated in the photoreceptors of glaucomatous retinas. 11 Hypoxia-inducible factor-1 is an oxygen-regulated transcriptional activator that often is considered to be

Full access
in American Journal of Veterinary Research

the basis of results of a CBC (including platelet count), prothrombin time, activated partial thromboplastin time, and buccal mucosal bleeding time. On the day of surgery, all eyes were treated by administration of 1 drop of tropicamide ophthalmic

Full access
in American Journal of Veterinary Research

reactivation in immunocompetent mature dogs have not been reported. Cyclosporine is an immunosuppressive agent that blocks recruitment and activation of T lymphocytes. 22 Topical ophthalmic cyclosporine formulations are commonly administered to dogs for

Full access
in American Journal of Veterinary Research

inflammatory process has been initiated, possibly by leptospiral infection or other ocular disease, there may be a general loss of ocular immune tolerance as a result of the presence of an inflammatory process. In this environment, activated antigen

Full access
in American Journal of Veterinary Research